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Combining Antidepressant Medication and Psychotherapy for Insomnia to Improve Depression Outcome
Not Recruiting
Trial ID: NCT00149825
Purpose
This study will examine the effectiveness of a combination of antidepressant medication and
sleep-focused psychotherapy to simultaneously treat sleep difficulties and depression.
Stanford Investigator(s)
Rachel Manber, PhD
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult)
Eligibility
Inclusion Criteria:
- Diagnosis of major depressive disorder
- HRSD(17) score of at least 14
- Presence and complaint of insomnia for at least 1 month
- Fluent in English
- Use of an effective form of contraception throughout the study
Exclusion Criteria:
- Other psychiatric disorders (e.g., bipolar disorder, post traumatic stress disorder,
obsessive compulsive disorder, eating disorder)
- Psychotic symptoms
- Serious, unstable, or terminal medical condition
- Axis II diagnosis of antisocial, schizotypal, or severe borderline personality
disorder
- Substance abuse
- Not willing to end other psychiatric treatment
- Previous electroconvulsive therapy or vagus nerve stimulation treatment during the
last year
- Sleep apnea, restless leg, or periodic limb movement disorder (to be ruled out after
first sleep study)
- Other sleep disorders
- Currently pregnant or breastfeeding
- History of seizure disorder
- Disease or condition that produces altered metabolism or hemodynamic responses
- Liver or kidney dysfunction
- Current use of any over the counter medications or herbs for mood or sleep benefits
(e.g., melatonin, valerian, kava, hop extract, St. John's Wort, SAMe)
Intervention(s):
drug: Escitalopram
behavioral: CBTI
behavioral: CTRL
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305