Trial Search Results

Combining Antidepressant Medication and Psychotherapy for Insomnia to Improve Depression Outcome

This study will examine the effectiveness of a combination of antidepressant medication and sleep-focused psychotherapy to simultaneously treat sleep difficulties and depression.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: National Institute of Mental Health (NIMH)

Stanford Investigator(s):

Intervention(s):

  • Drug: Escitalopram
  • Behavioral: CBTI
  • Behavioral: CTRL

Phase:

Phase 2

Eligibility


Inclusion Criteria:

   - Diagnosis of major depressive disorder

   - HRSD(17) score of at least 14

   - Presence and complaint of insomnia for at least 1 month

   - Fluent in English

   - Use of an effective form of contraception throughout the study

Exclusion Criteria:

   - Other psychiatric disorders (e.g., bipolar disorder, post traumatic stress disorder,
   obsessive compulsive disorder, eating disorder)

   - Psychotic symptoms

   - Serious, unstable, or terminal medical condition

   - Axis II diagnosis of antisocial, schizotypal, or severe borderline personality
   disorder

   - Substance abuse

   - Not willing to end other psychiatric treatment

   - Previous electroconvulsive therapy or vagus nerve stimulation treatment during the
   last year

   - Sleep apnea, restless leg, or periodic limb movement disorder (to be ruled out after
   first sleep study)

   - Other sleep disorders

   - Currently pregnant or breastfeeding

   - History of seizure disorder

   - Disease or condition that produces altered metabolism or hemodynamic responses

   - Liver or kidney dysfunction

   - Current use of any over the counter medications or herbs for mood or sleep benefits
   (e.g., melatonin, valerian, kava, hop extract, St. John's Wort, SAMe)

Ages Eligible for Study

18 Years - 75 Years

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Not Recruiting