Trial Search Results

T Cell Validation Study Using Blood Samples From Subjects With Recent Onset Type 1 Diabetes Mellitus

Type 1 diabetes is a condition that is caused in part by an abnormality of the immune system which occurs when T cells, which are part of the immune system, damage the insulin secreting cells (islet cells) in the pancreas. Although it is known that T cells are important mediators of the disease, progress in the development of reliable T cell assays has been modest. The purpose of this study is to learn which T cell assays are most reliable and reproducible so that the investigators can improve their understanding about how type 1 diabetes occurs.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Stanford Investigator(s):

Intervention(s):

  • Procedure: T Cell Proliferation and Autoreactivity Assays
  • Procedure: Cellular Immunoblot Assays
  • Procedure: Tetramer Studies
  • Procedure: Cytokine ELISPOT

Eligibility


Inclusion Criteria:

To be eligible, individuals with type 1 diabetes must be:

   - Diagnosed with type 1 diabetes within one year of first study visit

   - 8-35 years of age at time of first visit

   - Weigh > 40 kg (88 lbs) at time of first visit

   - Individuals who will serve as control subjects who do not have type 1 diabetes cannot
   have a first degree or second degree relative with type 1 diabetes.

Exclusion Criteria:

Individuals must not:

   - Have any major illness

   - Be taking any steroid medications

   - If female, should not be pregnant or breastfeeding.

Ages Eligible for Study

8 Years - 35 Years

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Alison Rigby
8772325182
Not Recruiting