Trial Search Results

ABT-751 With Chemotherapy for Relapsed Pediatric ALL

This is a phase I/II study of an investigational drug called ABT-751, produced by Abbott Laboratories, given in combination with chemotherapy drugs used to treat acute lymphoblastic leukemia (ALL) that has come back (recurred). The phase I portion of this study is being done to find the highest dose of ABT-751 that can be given safely in combination with other chemotherapy drugs. A safe dose is one that does not result in unacceptable side effects. After a safe dose for ABT-751 given with chemotherapy has been found, the study will add additional patients to find out if ABT-751 (given at the maximal safe dose) when given with additional chemotherapy is an effective therapy for the treatment of children with relapsed ALL. It is expected that approximately 15-35 children and young adults will take part in this study.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Therapeutic Advances in Childhood Leukemia Consortium


  • Drug: ABT-751
  • Drug: dexamethasone
  • Drug: PEG-asparaginase
  • Drug: doxorubicin
  • Drug: cytarabine
  • Drug: methotrexate
  • Drug: cyclophosphamide
  • Drug: 6-thioguanine


Phase 1


This is an abbreviated list...

Inclusion Criteria:

   - Patients must be less than 21 years of age to be participate in this study.

   - Patients must have relapsed acute lymphoblastic leukemia (ALL) without evidence of
   central nervous system (CNS) disease.

   - Patients must have adequate kidney, heart and liver function.

   - Must be able to swallow capsules.

Exclusion Criteria:

   - Patients who are pregnant or breast feeding.

   - Patients who have an allergy to Asparaginase products or sulfa-containing medications.

   - Patients who have an active uncontrolled infection.

   - Patients who have numbness or tingling in the hands or feet or constipation.

Ages Eligible for Study

N/A - 21 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Clare Twist
Not Recruiting