Trial Search Results

Defining the Role of Insulin Resistance in 'Idiopathic' Dilated Cardiomyopathy

This study will investigate the effects of rosiglitazone, a medicine commonly used to treat type 2 diabetes, on the utilization of glucose by the heart in patients with heart failure which is not due to heart attacks. The primary purpose of the study is to determine whether treatment with an insulin-sensitizing medication will improve the heart's ability to metabolize glucose (sugar).

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):

Intervention(s):

  • Drug: Rosiglitazone therapy

Phase:

N/A

Eligibility


Inclusion Criteria:

   - Diagnosis of nonischemic dilated cardiomyopathy, current NYHA class I-II congestive
   heart failure

   - History of Stage C-D heart failure with EF ≤ 40% during the course of the disease

   - Treatment with a stable comprehensive heart failure regimen for at least 3 months
   (including beta-blockers and ACE-inhibitors or angiotensin receptor blockers unless
   intolerant)

   - Age > 18 yrs

Exclusion Criteria:

   - Cardiomyopathy due to one of the following:

      - Ischemic heart disease

      - Primary valvular lesion

      - Hypertrophic cardiomyopathy

   - Cardiac resynchronization within the last 3 months

   - Transaminase values > 2.5 x upper limit of normal or history of liver disease

   - Diagnosis of diabetes mellitus by:

      - Diabetes previously diagnosed per patient history

      - 2 or more fasting glucose values > 125 mg/dl

   - Current NYHA class III or IV heart failure

   - Serum creatinine > 1.6 mg/dl

   - History of heart transplantation

   - Pregnancy or active breast feeding

   - Hospitalization for decompensated heart failure within 30 days prior to enrollment.

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Michael B Fowler, MB
650-723-7846
Not Recruiting