Trial Search Results

Study of the Effect of Sitagliptin on Glucose (Sugar) Metabolism in Patients With Heart Failure

This study will investigate the effects of sitagliptin, a medicine commonly used to treat type 2 diabetes, on the utilization of glucose by the heart in patients with heart failure which is not due to heart attacks. We hope to determine whether improving the heart's ability to use glucose in the blood may help improve the function of the heart as well. If so, this may suggest that even people who do not have frank diabetes but who do have heart failure may benefit from using this medication.

This study will also investigate the effect of sitagliptin on the body's use of sugar, and of the effect of sitagliptin on blood flow to the heart.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Merck Sharp & Dohme Corp.

Intervention(s):

  • Drug: Sitagliptin

Phase:

Early Phase 1

Eligibility


Inclusion Criteria:

   1. Diagnosis of nonischemic dilated cardiomyopathy, current NYHA class I-III congestive
   heart failure

   2. Treatment with a stable comprehensive heart failure regimen for at least 3 months
   (including beta-blockers and ACE-inhibitors or angiotensin receptor blockers unless
   intolerant)

   3. Age > 18 yrs

Exclusion Criteria:

   1. Cardiomyopathy primarily due to one of the following:

      1. Ischemic heart disease

      2. Primary valvular lesion

      3. Hypertrophic cardiomyopathy

   2. Cardiac resynchronization within the last 3 months

   3. Calculated creatinine clearance <30 ml/min or end-stage renal disease on dialysis.
   Creatinine clearance will be determined by the Cockcroft-Gault formula.

   4. Diagnosis of diabetes mellitus by:

      1. Diabetes previously diagnosed per patient history

      2. 2 or more fasting glucose values > 125 mg/dl

   5. History of heart transplantation

   6. Pregnancy or active breast feeding

   7. Hospitalization for decompensated heart failure within 30 days prior to enrollment.

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Ronald Witteles, MD
650-498-4343
Not Recruiting