Trial Search Results

Subcutaneous Botulinum Toxin for Cutaneous Allodynia

Superficial injection of Botulinum toxin has been advocated for cosmetic purposes but has also been reported to be helpful for some pain conditions. The investigators have observed prolonged profound analgesia following subcutaneous superficial injection of Botulinum Toxin Type A (BTA) in patients with certain types of neuropathic pain. The investigators propose to study if addition of BTA extends pain relief compared to placebo when injected subcutaneously into areas of cutaneous allodynia (the property that a normally non-noxious stimulus is perceived as painful).

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):


  • Drug: Botulinum Toxin A
  • Drug: Placebo - Saline




Inclusion Criteria:- Moderate to severe pain (greater than 4/10) of duration more than 6
months despite previous therapy.

   - The patient exhibits at least 80% pain relief following injection of local anesthetic
   subcutaneously into scar as assessed by change in NRS

   - The patient reports the presence of hyperalgesia, allodynia, dysesthesia, or
   hypoesthesia surrounding the scar

   - Age 18-100

   - Ability to read, write, and converse in English, provide informed consent, and follow
   study procedures

Exclusion Criteria:

   1. Any neuromuscular disorder such as myasthenia gravis, eaton lambert, muscular

   2. Any ongoing legal action related to their pain

   3. Allergy to local anesthetics

   4. A current or history of any severe psychiatric disorder

   5. History of any adverse reaction to botulinum toxin

   6. History of botulism

   7. Untreated infection

   8. Coagulopathy

   9. Females - positive pregnancy test

10. Surgery within the past 6 months at the site of the painful scar

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Rachel Moericke
Not Recruiting