Trial Search Results
Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications
The goal of this non-inferiority trial is to determine which type of routine care is the best for paramedics to stop someone from seizing.
Stanford is currently not accepting patients for this trial.
Collaborator: National Institute of Neurological Disorders and Stroke (NINDS)
- Drug: Intramuscular route of active treatment
- Drug: Intravenous route of active treatment
- Paramedics or reliable witnesses verify 5 minutes of either continuous seizure
activity or of repeated convulsive seizure activity where the patient does not regain
consciousness (operationally defined as meaningful speech or obeying commands) between
- Patient is still seizing at the time of paramedic treatment with study medications.
- Estimated weight equal to or greater than 13 kg.
- Subject to be transported to a RAMPART participating hospital.
- Major trauma as the precipitant of the seizure
- Hypoglycemia (as defined by local EMS protocol or a glucose < 60 mg/dL)
- Known allergy to midazolam or lorazepam
- Cardiac arrest or heart rate (HR) <40 beats per minute
- Sensitivity to benzodiazepines
- Medical alert tag marked with "RAMPART declined"
- Prior treatment of this seizure with diazepam autoinjector as part of another study
- Known pregnancy
Ages Eligible for Study
N/A - N/A
Genders Eligible for Study