Trial Search Results

Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications

The goal of this non-inferiority trial is to determine which type of routine care is the best for paramedics to stop someone from seizing.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Robert Silbergleit

Collaborator: National Institute of Neurological Disorders and Stroke (NINDS)

Stanford Investigator(s):

Intervention(s):

  • Drug: Intramuscular route of active treatment
  • Drug: Intravenous route of active treatment

Phase:

Phase 3

Eligibility


Inclusion Criteria:

   - Paramedics or reliable witnesses verify 5 minutes of either continuous seizure
   activity or of repeated convulsive seizure activity where the patient does not regain
   consciousness (operationally defined as meaningful speech or obeying commands) between
   seizures.

   - Patient is still seizing at the time of paramedic treatment with study medications.

   - Estimated weight equal to or greater than 13 kg.

   - Subject to be transported to a RAMPART participating hospital.

Exclusion Criteria:

   - Major trauma as the precipitant of the seizure

   - Hypoglycemia (as defined by local EMS protocol or a glucose < 60 mg/dL)

   - Known allergy to midazolam or lorazepam

   - Cardiac arrest or heart rate (HR) <40 beats per minute

   - Sensitivity to benzodiazepines

   - Medical alert tag marked with "RAMPART declined"

   - Prior treatment of this seizure with diazepam autoinjector as part of another study

   - Known pregnancy

   - Prisoners

Ages Eligible for Study

N/A - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Rosen Mann
6507212645
Not Recruiting