Trial Search Results
Comparative Renal Function of Young (18-45 Years) and Ageing (55 Years and Above) Kidney Donors
It is our purpose in this study to compare the kidney structure and function of older patients to that of young patients before and after removal of a single kidney for transplant donation and to examine the remaining kidney's ability to adapt and maintain function over time. More specifically, we aim to examine the effect of uninephrectomy on adaptive hyperfiltration in the remaining kidney. A secondary aim is to investigate whether subjects in the aging population undergo compensation to the same extent as younger subjects. We will also examine the compensatory rise in GFR (glomerular filtration rate) that follows uninephrectomy in both groups, and, again, compare the results in the aged versus young subjects. This will help in delineating the extent to which the aging population can be a potential source of living kidney donors for kidney transplantation.
It is also our purpose with this study to refine the tests to be used in the donor evaluation process so as to accurately identify ideal candidates for safe kidney donation.
Stanford is currently accepting patients for this trial.
- Procedure: CT angiogram of the remaining kidney.
- Procedure: Kidney Function study using Iothalamate & PAH as clearance markers
Inclusion Criteria:1. Patients who are over the age of 18. 2. Patients who are undergoing
surgical uninephrectomy for the purpose of living donation for transplantation 3. Adults
who had a single kidney removed for transplant donation 10-20 years ago.
4. All Patients enrolled in this study must be between the ages of 18 and 45 years or 55
years or older.
5. Patients undergoing surgery for kidney donation who exhibit mild hypertension controlled
with one medication. Any age accepted
Exclusion Criteria:1. Patients under the age of 18. 2. Patients between the ages of 46 and
54 3. Patients who are allergic to Inulin, Iothalamate, or PAH. 4. Women who are pregnant.
5. Other "Vulnerable Subjects"
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study