Trial Search Results

Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis

Chorioamnionitis is an infection of the placenta and amniotic membranes (bag of waters) surrounding the baby inside of a pregnant woman prior to delivery. This infection is somewhat common and is routinely treated with antibiotics given to the mother both before and after the baby is born. Currently it is not known what is the best choice of antibiotics to treat this type of infection, but commonly used treatments include Unasyn (ampicillin/sulbactam) or ampicillin/gentamicin. We plan to compare these two different antibiotic regimens to see if one is better than the other at treating and preventing bad outcomes from chorioamnionitis in women and babies.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Intervention(s):

  • Drug: Unasyn
  • Drug: Ampicillin/gentamicin

Phase:

Phase 2/Phase 3

Eligibility


Inclusion Criteria:

   1. Pregnant women in labor or undergoing induction of labor

   2. Greater than or equal to 18 years of age

   3. Diagnosed with chorioamnionitis as defined by maternal temperature > or = 38.0 degrees
   Centigrade plus at least one of the following: maternal tachycardia (heart rate >110),
   fetal tachycardia (fetal heart rate baseline >160), purulent amniotic fluid, uterine
   tenderness.

Exclusion Criteria:

   1. Allergy or adverse reaction to penicillin or ampicillin, gentamicin, or sulbactam

   2. Having received antibiotics for the treatment of preterm premature rupture of
   membranes or other condition within the last 7 days

   3. Acute or chronic renal disease or insufficiency (creatinine >1.0)

   4. Hearing loss

   5. Major fetal congenital anomalies or intrauterine fetal demise

   6. Neutropenia

   7. HIV

   8. Myasthenia gravis or other neuromuscular disorder

Ages Eligible for Study

18 Years - 55 Years

Genders Eligible for Study

Female

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Mara Greenberg
4158672051
Not Recruiting