Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma

Inclusion Criteria:

   - All osteosarcoma patients seen at COG institutions are eligible, including the
   following:

      - Newly diagnosed patients

      - Patients with recurrent disease who were not enrolled at the time of diagnosis

   - The following specimens from the initial biopsy (and/or definitive surgery if an
   up-front resection is performed) are required:

      - Paraffin embedded block OR 30 unstained slides

      - Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized
      whole blood

      - Fresh and frozen tumor specimens

   - Patients are not required to enter a therapeutic study to enroll on this study