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DNA Analysis of Tumor Tissue Samples From Patients With Diffuse Brain Stem Glioma
Not Recruiting
Trial ID: NCT00899834,7,45,17519,26500,50650,50652
Purpose
This multi-institutional study will prospectively collect tumor and constitutional tissue
samples from patients with diffuse brainstem glioma and other types of brainstem gliomas
either during therapy or at autopsy to perform an extensive analysis of genetic and molecular
abnormalities in these tumors.
Official Title
Comprehensive Molecular Analysis of Tumor Samples Derived From Patients With Diffuse Brainstem Glioma - A Pilot Study
Stanford Investigator(s)
Paul Graham Fisher, MD
Beirne Family Professor of Pediatric Neuro-Oncology, Professor of Pediatrics and, by courtesy, of Neurosurgery and of Epidemiology and Population Health
Eligibility
Inclusion Criteria
- Patients of any age with clinical and radiologic diagnosis of diffuse brainstem glioma
- Patients with other high-grade gliomas originating in the brainstem
- Patients with focal gliomas (WHO grade I/II) of the brainstem
- Enrollment in the current version of the St. Jude Tissue Bank protocol for patients
whose tissue samples were obtained at diagnosis and who received treatment at St. Jude
Children's Research Hospital (SJCRH), or correspondent tissue banking consent for
patients treated in other institutions if tissue was obtained prior to death (as
applicable, depending on the standard of each institution)
Exclusion Criteria
- Patients with any type of infiltrative low-grade (WHO grade II) or high-grade glioma
(WHO grade III and IV) originating outside the brainstem
- Patients harboring primary brainstem tumors with other histologic diagnoses (e.g.,
PNET)
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Michelle Monje