Once-Daily Oral Avatrombopag Tablets Used in Subjects With Chronic Liver Diseases and Thrombocytopenia Prior to Elective Surgical or Diagnostic Procedures

Key Inclusion Criteria:

   1. Males or females ≥ 18 years of age

   2. Thrombocytopenia (defined as a platelet count ≥ 10,000 - ≤ 50,000 (+15%)/mm^3 )

   3. Model for End-Stage Liver Disease (MELD) scores ≤ 24

   4. Chronic liver diseases due to one of the following three etiologies:

   Chronic Viral Hepatitis from one of the following categories

      - Chronic Hepatitis C (defined as the presence of anti-hepatitis C virus [HCV]
      antibodies and/or detectable serum HCV ribonucleic acid [RNA] levels)

      - OR chronic Hepatitis B (defined as the presence of hepatitis B surface antigen
      [HBsAg] and/or detectable serum hepatitis B virus [HBV] deoxyribonucleic acid
      [DNA])

      - OR chronic Hepatitis B and C co-infection (as defined by the above bullet points)

      - OR chronic Hepatitis C and history of alcohol abuse

      - OR chronic Hepatitis B and history of alcohol abuse

   NASH diagnosed as:

      - absence of serologic evidence of viral hepatitis and

      - convincing evidence of a history of minimal or no alcohol consumption, and

      - histologic picture of steatohepatitis OR

      - when histology is unavailable, then clinical, radiographic and laboratory
      evidence of NASH

   Alcoholic liver disease diagnosed as:

      - absence of serologic evidence of viral hepatitis and

      - history of heavy alcohol consumption and

      - histologic picture of alcoholic liver disease OR

      - when histology is unavailable, then clinical, radiographic and laboratory
      evidence of hepatitis combined with years of excessive alcohol intake

   5. Subjects who are scheduled to undergo an elective invasive procedure between 1 to 4
   days post last dose of study drug.

   6. Adequate renal function as evidenced by a calculated creatinine clearance ≥50
   mL/minute per the Cockcroft and Gault formula

   7. Life expectancy ≥3 months

Key Exclusion Criteria:

   1. Hepatic encephalopathy that cannot be effectively treated.

   2. Platelet transfusion within 7 days prior to the first dose of study drug

   3. Received blood products, eg, FFP and cryoprecipitate 7 days prior to the first dose of
   study drug

   4. Have surgical or diagnostic procedure scheduled during the Randomization Phase (Day 1
   to Day 8) of this study

   5. Interferon use within 2 weeks of Day 1

   6. Hormonal contraceptive use within 60 days of study entry

   7. History of human immunodeficiency virus (HIV) infection

   8. Any prohibited concomitant medications or therapy that cannot be discontinued by Visit
   1

   9. Active alcohol abuse, active alcohol dependence syndrome, drug abuse, or drug
   dependence within 6 months of the study start (unless participating in a controlled
   rehabilitation program)

10. Acute alcoholic hepatitis (chronic alcoholic hepatitis is allowed) within 6 months of
   the study start

11. History of any primary hematologic disorder

12. History of arterial or venous thrombosis, including thrombosis of any part of the
   splenic-mesenteric system

13. Any evidence of current portal vein thrombosis (PVT) as detected by Doppler sonography
   or appropriate MRI/CT imaging at Screening and/or within approximately 30 days prior
   to Screening

14. Any acute/active bleeding (gastrointestinal [GI], central nervous system [CNS], etc)

15. Uncompensated congestive heart failure (New York Heart Association [NYHA] Class III or
   IV)

16. Pre-diagnosed Immune Thrombocytopenic Purpura (ITP)

17. History of Myelodysplastic Syndrome (MDS)

18. Females who are pregnant (positive β-hCG test ) or breastfeeding

19. Current use of recreational drugs

20. Post-transplant patients

21. Subjects who have participated in another investigational trial within 30 days prior
   to Visit 1.