Trial Search Results
Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial
Preterm delivery is the most common cause of infant morbidity and mortality in the United States. Some women have episodes of preterm labor during their pregnancy which can be temporarily stopped. These women, however, are at high risk for delivering before term. At this time, we do not have sufficient evidence to use any medication to help prevent these women from delivering early. Recently, preliminary studies have shown that progesterone may help prevent some women at high risk for preterm delivery from delivering early. Our study will investigate whether progesterone can help this specific group of women, women with arrested preterm labor, deliver healthy infants at term.
Stanford is currently not accepting patients for this trial.
- Drug: Progesterone
- Drug: Polyethylene glycol&hydrogenated vegetable oil.
Phase 2/Phase 3
Inclusion Criteria:1. Pregnant women with arrested preterm labor between 24+0 to 33+6 weeks
2. Intact membranes 3. Singleton pregnancy 4. Greater than or equal to 18 years of age 5.
Cervical dilation less than or equal to 4cm
Exclusion Criteria:1. Any contraindication to on-going pregnancy 2. Placental abruption 3.
Placenta previa 4. Lethal fetal anomalies 5. Premature rupture of membranes 6. Multiple
gestation 7. Less than 18 years old 8. Known allergy to any component of the study
medication or placebo 9. Severe maternal medical illness
Ages Eligible for Study
18 Years - 55 Years
Genders Eligible for Study