Trial Search Results

Characterizing Knee Pain and Response to Surgery Using Local Biomarkers

The diagnosis and monitoring of clinically-significant pathologies of the knee remains challenging, and it is unknown why only some injuries become painful or respond to surgical intervention. The limitations of diagnostic magnetic resonance imaging result in arthroscopy that is not always beneficial. Elucidation of biochemical pathways underlying pain in this condition may aid patient selection for surgery and provide pharmacotherapeutic targets. Cytokines or a novel yet uncharacterized protein may be involved in pain following meniscus injury and diagnostic cytokine assay may help physicians differentiate patients that may benefit from arthroscopy from those that may not. Additionally, evaluating post-operative biochemical profiles may provide a method of monitoring surgical outcome and understanding post-operative continuation or remission of pain.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University


Inclusion Criteria:

•Adult patients with knee pain (acute or chronic) who had failed conservative treatment and
elected for arthroscopic management. Indications for surgery included the presence of
mechanical symptoms on history, a physical examination positive for McMurray's maneuver or
joint line tenderness or both, absence of severe joint space narrowing on plain
radiography, and the presence of grade III signal changes on MRI in an anatomic location
consistent with the history and physical examination.

Exclusion Criteria:

   - Less than 18 years old.

   - Recent (within three months) intra-articular corticosteroid injection and past or
   current medical history of autoimmune disease (i.e. rheumatoid arthritis).

   - In addition, no patients involved in a worker's compensation claim or personal injury
   litigation were enrolled in the study.

Ages Eligible for Study

18 Years - 90 Years

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Eric Leroux