Trial Search Results

Study is Designed to Assess the Safety and Tolerability of AZD4547 at Increasing Doses in Patients With Advanced Tumours

This study is primarily designed to assess the safety and tolerability of AZD4547 at increasing doses in patients with advanced solid malignancies and for whom no standard medication options are available. It also assesses the blood levels and action of AZD4547 in the body over a period of time.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

AstraZeneca

Stanford Investigator(s):

Intervention(s):

  • Drug: AZD4547
  • Drug: AZD4547
  • Drug: AZD4547

Phase:

Phase 1

Eligibility


Inclusion Criteria:

   - Minimum life expectancy of 12 weeks

   - The presence of a solid, malignant tumour that is resistance to standard therapies or
   for which no standard therapies exist

   - In the expansion for the study patients must have a tumour at least 1cm in size that
   can be measure using a CT or MRI scan, and provide a tumour sample to the sponsor
   company for testing of FGFR1 and/or 2 amplification

   - Expansion, 5 groups of advanced cancer

   - Solid tumours,FGFR1 and/or FGFR2 gene amplified

   - Squamous NSCLC, FGFR1 gene low & high amplified

   - Gastric adenocarcinoma, including the lower oesophagus/gastro-oesophageal junction,
   FGFR2 gene low & high amplified

   - Aged at least 25 years

Exclusion Criteria:

   - Treatment with any other chemotherapy, immunotherapy or anticancer agents within 3
   weeks before the first dose of study

   - An inability to be able to take the study medication

   - A bad reaction to AZD4547 or any drugs similar to it in structure or class.

Ages Eligible for Study

25 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Cancer Clinical Trials Office
650-498-7061
Not Recruiting