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4D-CT-based Ventilation Imaging for Adaptive Functional Guidance in Radiotherapy
Not Recruiting
Trial ID: NCT01034514
Purpose
To develop and investigate a novel radiotherapy technique for preserving lung function based
on a map of lung function.
Official Title
4D-CT-based Ventilation Imaging for Adaptive Functional Guidance in Radiotherapy
Stanford Investigator(s)
Billy W Loo, Jr, MD PhD FASTRO FACR
Professor of Radiation Oncology (Radiation Therapy)
Heather Wakelee
Winston Chen and Phyllis Huang Professor
Joseph Shrager
Professor of Cardiothoracic Surgery
A. Dimitrios Colevas, MD
Professor of Medicine (Oncology) and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS) and of Radiation Oncology (Radiation Therapy)
Eligibility
Inclusion Criteria:
- Eligible disease(s)/stage(s) AJCC Stage I, II, III or IV lung cancer of any histology
to be treated using radiotherapy will be eligible for this study. Note that we will
carefully consider the inclusion of cases with turbulent flow or greater flow
velocities (Cabahug et al., 1996; Crawford et al., 1990) and COPD cases (Magnant et
al., 2006) due to the impaction of aerosol particles in central airways.
- Allowable type and amount of prior therapy. Any types and amounts of prior therapy
will be allowed for this study.
- Age restriction and/or gender/ethnic restrictions
- Patients must be greater than or equal to 18 years of age.
- There are no gender or ethnic restrictions.
- Life expectancy restrictions - None.
- ECOG or Karnofsky Performance Status
- Not employed. Note that patients will need to be sufficiently healthy to undergo
audiovisual (AV) biofeedback to generate high quality 4D-CT images.
- Requirements for organ and marrow function None.
- Ability to understand and the willingness to sign a written informed consent document.
Exclusion Criteria:
Children (less than 18 years of age), pregnant women, Stanford employees or students, or
prisoners will be excluded from this study.
Intervention(s):
device: Real-time Position Management system
device: Discovery ST multislice PET/CT scanner
device: Infinia Hawkeye SPECT/CT gamma camera
device: Pinnacle3 treatment planning system
device: SKYLight nuclear camera
drug: DTPA
drug: TECHNETIUM TC 99M MAA
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Cancer Clinical Trials Office
650-498-7061