Trial Search Results

Study of Exercise Training in Hypertrophic Cardiomyopathy

The investigators propose a pilot randomized controlled trial to determine the safety and potential benefits of moderate intensity exercise in patients with hypertrophic cardiomyopathy. The investigators hypotheses are that exercise parameters derived from a baseline cardiopulmonary exercise test will target an appropriately safe level of exercise intensity that will not cause significant arrhythmias or exacerbate symptoms and that exercise training for 4 months will result in significant improvements in peak oxygen consumption (peak VO2) and quality of life, with neutral effects on the clinical characteristics.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

University of Michigan

Collaborator: Stanford University

Stanford Investigator(s):

Intervention(s):

  • Behavioral: Exercise training

Phase:

N/A

Eligibility


Inclusion Criteria:

   - Age ≥ 18 years and ≤ 80.

   - Diagnosis of HCM, defined by the presence of unexplained left-ventricular hypertrophy
   > 13 mm in any wall segment.

   - Agreement to be a participant in the study protocol and willing/able to return for
   follow-up.

Exclusion Criteria:

   - History of exercise-induced syncope or arrhythmias (ventricular tachycardia or
   non-sustained ventricular tachycardia).

   - Medically refractory left ventricular outflow tract obstruction being evaluated for
   septal reduction therapy.

   - Less than 3 months post septal reduction therapy (surgery or catheter based
   intervention).

   - Hypotensive response to exercise (> 20 mm Hg drop in systolic blood pressure from peak
   blood pressure to post exercise blood pressure).

   - Pregnancy.

   - Implantable Cardioverter-Defibrillator (ICD) placement in last 3 months or scheduled.

   - Left ventricular systolic dysfunction (left ventricular ejection fraction < 55% by
   echocardiography).

   - Worsening clinical status in the last 3 months, advanced heart failure (New York Heart
   Association class IV symptoms) or angina (Canadian Cardiovascular Society class IV
   symptoms).

   - Life expectancy less than 12 months.

   - Inability to exercise due to orthopedic or other non-cardiovascular limitations.

   - Unwillingness to refrain from competitive sports, burst activity, or heavy isometric
   exercise for the duration of the study.

Ages Eligible for Study

18 Years - 80 Years

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Heidi Salisbury, BS, RN, MSN
650-736-7878
Not Recruiting