Trial Search Results

Phase 1 Nilotinib in Steroid Dependent/Refractory Chronic Graft Versus Host Disease

PRIMARY OBJECTIVES:

Determine the safety and tolerability of nilotinib in steroid dependent / refractory cGVHD.

SECONDARY OBJECTIVES:

Determine the clinical efficacy of nilotinib in steroid dependent / refractory cGVHD.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Novartis

Stanford Investigator(s):

Intervention(s):

  • Drug: Nilotinib

Phase:

Phase 1

Eligibility


Inclusion Criteria:5.1.1 Steroid dependent/refractory cGVHD defined as:

   1. Dependent disease - Persistent cGVHD manifestations requiring a glucocorticoid dose >=
   prednisone 0.25 mg/kg/day (0.5 mg/kg po qod) for at least 12 weeks.

   2. Refractory disease - Progressive cGVHD manifestations despite treatment with a
   glucocorticoid dose >= prednisone 0.5 mg/kg/day (1 mg/kg po qod) for at least 4 weeks.

5.1.2 Any previous treatments for cGVHD (except nilotinib). Participants may have received
nilotinib for other reasons besides cGVHD such as leukemia or solid tumor.

5.1.3 Participants must be receiving baseline systemic glucocorticoid therapy for cGVHD at
study entry. The dose of steroids must be stable for 14 days prior to starting nilotinib.

5.1.4 At the time of trial enrollment, participants may be receiving one or two other
immunosuppressive therapies in addition to glucocorticoids. Immunosuppressant doses must be
stable for 14 days prior to starting nilotinib. Monoclonal T or B cell antibodies must be
discontinued at least 28 days before starting nilotinib.

5.1.5 Chronic GVHD manifestations that can be followed on physical or laboratory exam. A
list of potential manifestations is presented in Appendix D.

   1. Skin changes

   2. Oral mucosa changes

   3. Hepatic dysfunction

5.1.6 >= 18 years old

5.1.7 Life expectancy >= 6 months.

5.1.8 Karnofsky performance status >= 60 (defined as being unable to work, able to live at
home, and able to care for most personal needs but requiring occasional assistance from
others).

5.1.9 Laboratory parameters:

   1. Creatinine < 1.5 x ULN

   2. ANC > 1.5 x 10^9/L

   3. Platelets > 100 x 10^9/L

   4. Total bilirubin < 1.5 x ULN

   5. AST (SGOT) and ALT (SGPT) < 2.5 x ULN

   6. Serum amylase and lipase <= 1.5 x ULN

   7. Alkaline phosphatase <= 2.5 x ULN

   8. Patients must have the following laboratory values within normal limits at the local
   institution lab or corrected to within normal limits with supplements prior to the
   first dose of study medication:

Potassium Magnesium Phosphorus Calcium

5.1.10 Oxygen saturation during exertion maintained at >= 88% on room air.

5.1.11 Ability to understand and willingness to sign a written informed consent form.

5.1.12 Females with reproductive potential must have a negative pregnancy test <= 7 days
before starting nilotinib. Reproductive potential will be defined as having at least 1
menstrual period in the past 12 months. Male and female subjects with reproductive
potential agree to the use of barrier contraception during their treatment and for up to 3
months after the last dose.

5.1.13 Careful rationalization of concomitant medications with the intent to discontinue or
change to alternative medications when any concomitant medications are identified that have
the potential to prolong the QTcB interval or are associated with an increased risk of
torsades de pointes. (Appendix B)

5.1.14 . Careful rationalization of concomitant medications with the intent to discontinue
or change to alternative medications if any concomitant medications are identified to be
strong CYP3A4 inhibitors. (Appendix C)

5.1.15 Myeloablative or non-myeloablative allogeneic hematopoietic cell transplant.

Exclusion Criteria:5.2.1 Currently receiving or has received within 28 days of starting
study drug nilotinib or any other tyrosine kinase inhibitor.

5.2.2 Received any anti-T or anti-B cell monoclonal antibody <= 28 days prior to the
anticipated start of study drug.

5.2.3 Currently receiving > two immunosuppressants other than glucocorticoids.

5.2.4 Currently receiving a calcineurin inhibitor and sirolimus

5.2.5 Received any investigational agents <= 28 days before starting nilotinib.

5.2.6 Impaired cardiac function including any one of the following:

   1. Clinically significant resting brachycardia (<50 beats per minute).

   2. QTc > 450 msec on baseline ECG. If QTc >450 msec and electrolytes are not within
   normal ranges, electrolytes should be corrected and then the patient re-screened for
   QTc.

   3. Myocardial infarction within 12 months prior to starting study.

   4. Other clinically significant uncontrolled heart disease (e.g. unstable angina,
   congestive heart failure or uncontrolled hypertension).

   5. History of or presence of clinically significant ventricular or atrial
   tachyarrhythmias. (including congenital long QT syndrome or a known family history of
   congenital long QT syndrome)

5.2.7 Allogeneic cell infusion within 100 days

5.2.8 Uncontrolled infections not responsive to antibiotics, antiviral medicines, or
antifungal medicines.

5.2.9 Progressive malignant disease including post transplant lymphoproliferative disease.

5.2.10 Any secondary malignancy except basal and squamous cell carcinoma of the skin within
the past five years.

5.2.11 Nilotinib intolerance or hypersensitivity. 5.2.12 Impaired gastrointestinal (GI)
function or GI disease that may significantly alter the absorption of study drug (e.g.,
ulcerative diseases, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, small
bowel resection or gastric bypass surgery).

5.2.13 Acute or chronic pancreatic disease 5.2.14 Major surgery within 4 weeks prior to Day
1 of the study or who have not recovered from prior surgery.

5.2.15 Subject is pregnant, breast-feeding, or of childbearing potential without a negative
serum or urine pregnancy test within 7 days of enrollment. Male or female patients of
childbearing potential unwilling to use effective contraceptive precautions throughout the
trial.

5.2.16 Subject not willing to comply with treatment or response evaluation (including
associated procedures such as skin biopsy).

5.2.17 Subject has a concurrent illness which in the opinion of the investigator may
interfere with the treatment and evaluation of the patient.

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Joanne Otani
650-721-2372
Not Recruiting