Trial Search Results
Combined Blood Stem Cell and Kidney Transplant of One Haplotype Match Living Donor Pairs.
The Stanford Medical Center Program in Multi-Organ Transplantation and the Division of Bone marrow Transplantation are enrolling patients into a research study to determine if donor stem cells given after a living related one Haplotype match kidney transplantation will change the immune system such that immunosuppressive drugs can be completely withdrawn.
Stanford is currently accepting patients for this trial.
Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
- Drug: Immune Tolerance
1. All consenting adult (> 18 years of age) living donor renal transplant recipients at
Stanford University Medical Center who have a one haplotype match donor.
2. Patients who agree to participate in the study and sign an Informed Consent.
3. Patients who have no known contraindication to administration of rabbit ATG or
4. Males and females of reproductive potential who agree to practice a reliable form of
contraception for at least 24 months posttransplant.
5. ABO compatible.
1. Previous treatment with rabbit ATG or a known allergy to rabbit proteins.
2. History of malignancy with the exception of non-melanoma skin malignancies.
3. Pregnant women or nursing mothers.
4. Serological evidence of HIV, Hepatitis B or Hepatitis C infection.
5. Seronegative for Epstein-Barr virus, if donor is seropositive.
6. Leukopenia (with a white blood cell count < 3000/mm3) or thrombocytopenia (with a
platelet count < 100,000/mm3).
7. Panel Reactive Antibody greater than 20% or demonstration of donor specific antibody
8. Prior organ transplantation
9. High risk of primary kidney disease recurrence (i.e.FSGS)
Ages Eligible for Study
18 Years - 60 Years
Genders Eligible for Study