Trial Search Results

Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma

The outcome of patients with metastatic Ewings Sarcoma is poor with current standard of care chemotherapy, with less than 30% survival. Based on recent encouraging pediatric literature we have designed this trial to improve the outcome of patients with metastatic Ewings sarcoma using Irinotecan and Temozolomide in addition to standard chemotherapy.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Amgen


  • Drug: Irinotecan
  • Drug: Vincristine
  • Drug: Temozolomide
  • Drug: Doxorubicin
  • Drug: Cytoxan
  • Drug: Pegfilgrastim


Phase 2


Inclusion Criteria:

   - Histologically or cytologically confirmed diagnosis of metastatic Ewing's sarcoma.

   - Patients must have measurable disease defined as lesions that can be measured by
   medical imaging techniques such as CT or MRI. Ascites, pleural fluid, bone marrow
   disease, lesions seen on scan will not be considered measurable.

   - Patients must have metastatic disease.

   - Age 13 years or older

   - Life expectancy of at least 3 months.

   - ECOG performance status of <= 3.

   - Normal hepatic function (Direct bilirubin <1.5mg/dl, SGOT or SGPT <3x upper limit of

   - Left Ventricular Ejection fraction of at least 50%.

   - Adequate renal function: Creatinine clearance >= 50 ml/min or Serum creatinine < 1.5 x
   ULN for age.

   - Adequate bone marrow reserve (defined as an absolute peripheral granulocyte count of
   >=1500/mm3, platelet count of >=75,000/mm3); unless bone marrow infiltrated with
   metastatic Ewing's sarcoma; ANC >= 500 and Platelet >= 50,000 mm3.

   - Ability to understand and willing to sign a written informed consent document.

   - Patients of childbearing potential must agree to use an effective method of

Exclusion Criteria:

   - No prior chemotherapy for Ewing's sarcoma; No prior doxorubicin, temozolomide or

   - Known hypersensitivity to any of the components of the protocol drugs.

   - Clinically significant unrelated systemic illness (such as serious infections
   requiring active systemic intravenous antibiotic therapy; cardiovascular disease
   [congestive heart failure, recent myocardial infarction, unstable angina, inadequately
   controlled hypertension].

   - No prior history of chronic diarrhea, bowel obstruction, Crohn's disease or ulcerative

   - Pregnant or nursing woman are not included in the study.

   - HIV-positive patients will be excluded from the study due to risk of infection or
   other serious side effects.

   - Other medical, psychiatric or social condition incompatible with study treatment.

Ages Eligible for Study

13 Years - N/A

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305