Trial Search Results

Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI

This pilot trial studies the differentiation of bone sarcomas and osteomyelitis with ferumoxytol-enhanced magnetic resonance imaging (MRI). Imaging procedures that allow doctors to more accurately differentiate between malignant bone sarcomas and osteomyelitis may help in diagnosing patients correctly and may result in more timely treatment.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):

Intervention(s):

  • Drug: Feraheme
  • Procedure: MR Scan

Phase:

N/A

Eligibility


Inclusion Criteria:

   - Suspected or confirmed diagnosis of a bone sarcoma or osteomyelitis

   - Symptomatic osteonecrosis (ON) of the femur or proximal tibia with MR signal
   abnormalities that involve more than 50% of the respective joint surface, but no
   evidence of epiphyseal collapse

   - There will be no gender/race-ethnic restrictions

   - In this pediatric & adult study, the participant or parent/guardian is consented, and
   the patient when a minor is given an assent form and involved in the discussion as
   appropriate

Exclusion Criteria:

   - Contraindication to MRI

   - Presence of metal implants

   - Need for sedation or anesthesia

   - Claustrophobia

   - Hemosiderosis/hemochromatosis (patients can still be included in the 2nd branch
   without receiving ferumoxytol)

   - There will be no restrictions regarding use of other investigational agents

   - Patients with evidence of iron overload, hemosiderosis/hemochromatosis will be
   excluded for the bone sarcoma study; however, they can undergo MRI exam without
   ferumoxytol enhancement for the ON study

   - History of allergic reactions to similar compounds will be obtained and patients with
   positive history of allergic reactions will be excluded from the study

   - Pregnancy or nursing patients will be excluded from the study; a pregnancy test will
   be done prior to the MR examination for postmenarchal teenage girls, in whom pregnancy
   may be possible; only patients with a negative pregnancy test will be included in the
   study

Ages Eligible for Study

8 Years - 40 Years

Genders Eligible for Study

All

Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Anne Muehe
(650) 724-3191
Recruiting