Trial Search Results

Diffusion Weighted Imaging Evaluation for Understanding Stroke Evolution Study-2 (DEFUSE-2)

Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution Study 2 (DEFUSE 2) is a multi-center pilot study to determine if cerebral perfusion imaging can help identify which patients, who are ineligible for intravenous tissue plasminogen activator (iv tPA) therapy or have failed iv tPA therapy, are most likely to benefit from an endovascular clot removal procedure.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: National Institute of Neurological Disorders and Stroke (NINDS)

Stanford Investigator(s):

Eligibility


Inclusion Criteria:

   1. Age 18 years and older

   2. Clinical diagnosis of ischemic stroke and a score of 5 or more points in the NIHSS.

   3. Planned to undergo intra-arterial (IA) therapy for acute hemispheric stroke (Either as
   primary therapy or as adjuvant therapy following intravenous tPA treatment)

   4. Planned to have a standard MRI including perfusion imaging and MR angiography of the
   circle of Willis (MRA) prior to IA therapy

   5. Intra-arterial thrombectomy can be started within 90 minutes of completion of MRI scan
   and within 12 hours of symptom onset. (Start of IA therapy is defined as the time of
   insertion of the femoral artery sheath; Time of brain scan is defined as the time that
   the scan is completed)

   6. Able to obtain informed consent (informed consent should be obtained prior to the
   baseline MRI scan).

Exclusion Criteria:

   1. Any pre-existing neurological illness resulting in a modified Rankin Scale Score of 3
   or higher prior to the qualifying stroke

   2. Pregnancy

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Not Recruiting