A Study of CDX-1127 (Varlilumab) in Patients With Select Solid Tumor Types or Hematologic Cancers

Inclusion Criteria:

Among other criteria, patients must meet the following conditions to be eligible for the
study:

   1. 18 years of age or older.

   2. Body Weight ≤ 120 kg.

   3. Histologic diagnosis of either a B-cell or T-cell hematologic malignancy known to
   express CD27 or one of the following solid tumors: metastatic melanoma, renal (clear)
   cell carcinoma, hormone-refractory prostate adenocarcinoma, ovarian cancer, colorectal
   adenocarcinoma or non-small cell lung cancer. For the solid tumor expansion cohorts,
   enrollment is limited to the following solid tumors: melanoma and renal cell
   carcinoma.

   4. Tumor must be recurrent or treatment refractory with no remaining alternative,
   approved therapy options, with the following exception: melanoma patients enrolled in
   the expansion phase must have previously received ipilimumab and, for patients with
   the BRAF V600E mutation, vemurafenib, or have been offered such therapies and refused,
   and patients must have progressive disease subsequent to previous therapies.

   5. Measurable or evaluable disease.

   6. Have adequate blood, bone marrow, liver and kidney function as determined by
   laboratory tests.

   7. If of childbearing potential (male or female), agree to practice an effective form of
   contraception during study treatment.

   8. Have little or no side effects remaining from prior cancer therapies.

   9. Provide written informed consent.

Exclusion Criteria:

Among other criteria, patients who meet the following conditions are NOT eligible for the
study:

   1. Known prior primary or metastatic brain or meningeal tumors.

   2. Receiving treatment with immunosuppressive agents, including any systemic steroids.

   3. Active infection requiring systemic therapy, known HIV infection, or positive test for
   hepatitis B surface antigen or hepatitis C.

   4. Is being treated for anti-coagulation (i.e. warfarin) for reasons other than catheter
   patency.

   5. Women who are pregnant or lactating.

   6. Prior allogeneic bone marrow transplant.

   7. Autologous bone marrow transplant within 100 days of first dosing.

   8. Recent chemotherapy or other anti-cancer therapy (within 2 - 14 weeks depending on
   treatment type).

   9. Systemic radiation therapy within 4 weeks or prior focal radiotherapy within 2 weeks
   prior to first dosing.