Trial Search Results

Vitamin D and Breast Cancer: Does Weight Make a Difference?

This is a research study of the effect of Vitamin D on breast cancer. We hope to learn whether Vitamin D can change characteristics of certain genes in a breast cancer tumor that affect its growth. We believe some of these characteristics may be influenced by body weight.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Melinda Telli

Intervention(s):

  • Drug: Vitamin D3
  • Drug: Vitamin D3

Phase:

N/A

Eligibility


Inclusion Criteria:

   - 3.1.1 Women who have undergone a core needle biopsy demonstrating an operable breast
   cancer whom have not yet had any further therapy.

   - 3.1.2 No prior therapy for breast cancer.

   - 3.1.4 Age 18 years or older.

   - 3.1.5 Any menopausal status

   - 3.1.6 Planned surgical resection of breast cancer or repeat core biopsy tissue
   sampling prior to initiation of neoadjuvant systemic chemotherapy.

   - 3.1.7 Availability of tissue blocks from initial core needle biopsy.

   - 3.1.8 Signed informed consent.

   - 3.1.9 Willing to discontinue use of all supplements containing Vitamin D for the
   duration of the study, and take only the Vitamin D provided by the study.

Exclusion Criteria:

   - 3.2.1 Presence of any Metastatic lesion.

   - 3.2.2 History of parathyroid disease, hypercalcemia, or kidney stones.

   - 3.2.3 History of SERM or aromatase inhibitor therapy.

   - 3.2.4 Taking metformin.

   - 3.2.5 History of renal failure requiring dialysis or kidney transplantation.

   - 3.2.6 Women who are known to be pregnant or who are nursing. (As vitamin D does not
   have toxicity to the fetus, a negative pregnancy test is not a requirement to
   participate in the study.)

   - 3.2.7 Patients planned for surgical therapy of their breast cancer or initiation of
   systemic chemotherapy, that would not allow for at least 7 days of vitamin D
   intervention

   - 3.2.9 Any condition potentially interfering with subjects ability to comply with
   taking study medication.

   - 3.2.10 Any medical condition that would potentially interfere with vitamin D
   absorption.

   - 3.2.11 Current participation in another research study that would increase risk to
   subject, in the opinion of the investigators.

   - 3.2.12 Patients currently taking more than 2000 IU of Vitamin D.

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

Female

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
ccto-office@stanford.edu
650-498-7061
Not Recruiting