Pioglitazone in Patients With Mood Disorders

Inclusion Criteria:

   - Age between 20 and 65 years

   - BMI between 25 and 35

   - Diagnosis of unipolar, non-psychotic, non-melancholic major depressive disorder (MDD)
   or depressive episode of bipolar disorder (Bipolar I, II or NOS)

   - Depression severity as defined by score of < 12 on the 21-item Hamilton Rating Scale
   for Depression and no psychiatric admission within 6 months from study entry and no
   suicide attempt within the last 12 months

   - Willingness to sign human subjects consent form

Exclusion Criteria:

   - Diagnosis of possible or probable cognitive impairment

   - For women only: pregnancy, breastfeeding

   - Personal history of Type I or Type II diabetes

   - Unstable cardiovascular disease or other major medical condition, or history of
   myocardial infarction within the previous year

   - Significant cerebrovascular disease, as evidenced by neurological examination,
   uncontrolled hypertension (systolic blood pressure > 170 or diastolic blood pressures
   > 100)

   - Current drug or alcohol abuse

   - History of neurological disorder, e.g. multiple sclerosis, stroke etc

   - Use of any drug that may significantly affect psychometric testing or the insulin
   testing