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A High Resolution Pharmacokinetic/Pharmacodynamic Model of Propofol in Morbidly Obese Subjects
Not Recruiting
Trial ID: NCT01591148
Purpose
This study will determine how morbid obesity affects the distribution and metabolism of the
drug propofol. The investigators hypothesize that propofol will be distributed and
metabolized differently in morbidly obese subjects as compared to normal weight subjects.
Official Title
A High Resolution Pharmacokinetic/Pharmacodynamic Model of Propofol in Morbidly Obese Subjects
Eligibility
Inclusion Criteria:
- adult age (ages 18-70)
- body mass index greater than 40 or between 20-25
- American Society of Anesthesiologists Class I, II, or III
- undergoing elective surgical procedure requiring general anesthesia
Exclusion Criteria:
- evidence of cardiovascular or pulmonary disease
- kidney or liver dysfunction
- drug allergy to propofol
- history of difficult airway
- on prescribed or over the counter anxiolytics, antipsychotics, or sleeping aids
- unable to speak or understand English
Intervention(s):
drug: propofol
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Jerry Ingrande, M.D., M.S.
650-723-7377