Trial Search Results

Genome-Wide Gene Expression Profiling of Patients With ITP Receiving Thrombopoietin Mimetics


Ineffective platelet production has been proven to play a role in the etiology of Immune Thrombocytopenia (ITP) in addition to increased platelet destruction. The second-generation thrombopoietin (TPO) mimetics have shown good efficacy in boosting platelet counts in the great majority of patients with chronic ITP in several clinical trials.1, 2 Nevertheless, about 20% of patients with ITP fail to respond to the TPO mimetic treatment. Those treatment-resistant patients are un-characterized and the reasons for the lack of response have not been studied. The identification of predictive blood biomarkers of patients' response to treatment will be useful in reducing both cost and potential side effects; and it will be of equal importance and interest to investigate the molecular mechanisms underlying the patients' heterogeneous responses to TPO mimetic treatment.

Specific Aims:

1. To identify blood classifier genes which correlate with patients' response to TPO mimetic treatment.

2. To compare the blood gene expression changes in responders and non-responders after TPO mimetic treatment and explore the possible molecular mechanisms accounting for the non-responsiveness to the treatment.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Weill Medical College of Cornell University

Stanford Investigator(s):




Inclusion Criteria:

   - clinical diagnosis of ITP TPO treatment

Exclusion Criteria:

   - thrombocytopenia not due to ITP

Ages Eligible for Study

N/A - N/A

Genders Eligible for Study


Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
James L Zehnder, MD