Trial Search Results

Arsenic Trioxide in Treating Patients With Basal Cell Carcinoma

This pilot clinical trial studies arsenic trioxide in treating patients with basal cell carcinoma. Drugs used in chemotherapy, such as arsenic trioxide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stop them from dividing

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: The V Foundation for Cancer Research

Stanford Investigator(s):

Intervention(s):

  • Drug: arsenic trioxide

Phase:

Phase 1/Phase 2

Eligibility


INCLUSION CRITERIA

   - Basal cell carcinoma (BCC)

   - Ineligible for curative locoregional treatment and have either progressed on, did not
   tolerate, unwilling to try or ineligible for investigational smoothened antagonist
   such as vismodegib (GDC 0449), XL 139 (BMS 833923), IPI- 926, LDE225 and PF-04449913

   - Life expectancy estimate > 3 months

   - Performance status Eastern Cooperative Oncology Group (ECOG) 0-2

   - Absolute neutrophil count ≥ 1,500/mcL

   - Platelets ≥ 100,000/mcL

   - Total bilirubin within normal institutional limits

   - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
   [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
   ≤ 2.5 x institutional upper limit of normal

   - Creatinine within normal institutional limits

   - Corrected QT interval (QTC) by 12 lead electrocardiogram (EKG) < 450 msecs

   - Serum potassium within normal limits

   - Magnesium within normal limits

   - Calcium within normal limits

   - Ability to understand and the willingness to sign a written informed consent document

   - Evaluable tumor and be potentially eligible for pre and post ATO tumor biopsy

   - Receiving potassium wasting diuretics or amphotericin, while not excluded, must be
   noted to have theoretically increased arrhythmia risks with ATO

EXCLUSION CRITERIA

   - Concurrent use of other Investigational agents

   - Cardiac arrhythmias

   - Uncontrolled intercurrent illness including, but not limited to, ongoing or active
   infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
   arrhythmia, recurrent seizure history or psychiatric illness/social situations that
   would limit compliance with study requirements

   - Pregnant or lactating

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
ccto-office@stanford.edu
650-498-7061
Not Recruiting