Trial Search Results

Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors

This randomized phase II trial studies how well giving temozolomide with or without capecitabine works in treating patients with advanced pancreatic neuroendocrine tumors. Drugs used in chemotherapy, such as temozolomide and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether temozolomide is more effective with or without capecitabine in treating patients with advanced pancreatic neuroendocrine tumors.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Eastern Cooperative Oncology Group

Collaborator: National Cancer Institute (NCI)

Stanford Investigator(s):

Intervention(s):

  • Drug: temozolomide
  • Drug: capecitabine
  • Other: laboratory biomarker analysis

Phase:

Phase 2

Eligibility


Inclusion Criteria:

   - Patient must have histologically or pathologically confirmed locally unresectable or
   metastatic low or intermediate grade pancreatic neuroendocrine tumor, excluding small
   cell carcinoma

   - Patient must have measurable disease by Response Evaluation Criteria in Solid Tumors
   (RECIST) 1.1 criteria; baseline measurements and evaluations of all sites of disease
   must be obtained =< 4 weeks prior to randomization and must be acquired by multiphasic
   CT or contrast magnetic resonance imaging (MRI)

   - Date of last documented disease progression must be =< 12 months from date of
   randomization

   - Patient must not have received prior temozolomide, dacarbazine (DTIC), or
   capecitabine, or 5-FU (fluorouracil) therapy

   - Prior everolimus and/or sunitinib therapy is allowed, so long as it was discontinued
   >= 4 weeks prior to randomization

   - Concurrent somatostatin analogues are allowed provided that patients

      - Have been on stable doses for 8 weeks and

      - Have documented disease progression on that dose

   - Patients may not be receiving any other investigational agents while on study
   treatment

   - Patients may not be receiving Coumadin while on treatment; other anticoagulants are
   allowed

   - Leukocytes >= 3,000/mm^3

   - Absolute neutrophil count >= 1,500/mm^3

   - Hemoglobin >= 9 g/dL

   - Platelets >= 100,000/mm^3

   - Total bilirubin =< institutional upper limit of normal (ULN) or =< 1.5 X institutional
   ULN (if the patient has liver metastases)

   - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
   [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
   =< 3 X institutional ULN or (=< 5 X institutional ULN if the patient has liver
   metastases)

   - Serum creatinine =< 1.5 X institutional ULN

   - Patient must have Eastern Cooperative Oncology Group (ECOG) performance status 0-1

   - Patient must have life expectancy >= 12 weeks

   - Patients with either clinically apparent central nervous system metastases or
   carcinomatous meningitis are ineligible

   - Patients must NOT have active or uncontrolled infection or serious medical or
   psychiatric illness

   - Patients must NOT have history of allergic reactions attributed to compounds of
   similar chemical or biologic composition to temozolomide or capecitabine

   - Patient must NOT have absorption issues that would limit the ability to absorb study
   agents

   - Patients with a history of the following within =< 12 months of study entry are not
   eligible:

      - Arterial thromboembolic events

      - Unstable angina

      - Myocardial Infarction

   - Patients with symptomatic peripheral vascular disease are not eligible

   - Patients must NOT have previous or concurrent malignancy; exceptions are made for
   patients who meet any of the following conditions:

      - Non-melanoma skin cancer, in situ cervical cancer, or breast cancer in situ OR

      - Prior malignancy completely excised or removed and patient has been continuously
      disease free for > 5 years OR

      - Prior malignancy cured by non-surgical modalities and patient has been
      continuously disease free for > 5 years

   - Women must not be pregnant or breast-feeding; all females of childbearing potential
   must have a blood test or urine study within =< 2 weeks prior to randomization to rule
   out pregnancy; a female of childbearing potential is any woman, regardless of sexual
   orientation or whether they have undergone tubal ligation, who meets the following
   criteria:

      - Has not undergone a hysterectomy or bilateral oophorectomy; or

      - Has not been naturally postmenopausal for at least 24 consecutive months (i.e.,
      has had menses at any time in the preceding 24 consecutive months)

   - Women of childbearing potential and sexually active males must be strongly advised to
   use an accepted and effective method of contraception or to abstain from sexual
   intercourse for the duration of their participation in the study; should a woman
   become pregnant while participating in this study, she should inform her treating
   physician immediately; if a man impregnates a woman while participating in this study,
   he should inform his treating physician immediately

   - Patient must be able to swallow pills

   - Patient must be able to tolerate CT or magnetic resonance (MR) imaging including
   contrast agents as required for their treatment and the protocol

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
CCTO
650-498-7061
Not Recruiting