Trial Search Results

Identifying Biological Markers for Severe Depression

The primary objective of this study is to investigate the biological components of major depression. The investigators are particularity interested in genetic variation and how it contributes to cortisol (because cortisol is higher in severe depression than mild depression or healthy controls) and how it contributes to clinical symptoms, especially suicidal ideation/behavior and psychosis.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: Pritzker Consortium

Stanford Investigator(s):

Eligibility


Inclusion criteria for depressed patients:

   1. Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV) diagnosis
   of Unipolar Major Depressive Disorder with or without psychotic features.

   2. 21-item Hamilton Depression Rating Scale (HDRS) score greater than or equal to 21.

   3. Thase Core Endogenomorphic Scale score greater than or equal to 8 on the items
   included in the 21-item HDRS.

   4. Between 18 - 70 years of age.

   5. If currently taking antipsychotic, antidepressant, anticonvulsant, and/or
   mood-stabilizing medications, must be stable on the medication for at least one-week
   prior to entering the study.

   6. Pre-existing (current) primary treating psychiatrist for subjects with psychotic
   features.

   7. Any secondary diagnoses from the anxiety disorder spectrum is acceptable. Primary
   pre-existing chronic Obsessive-Compulsive Disorder (OCD) will be an exclusion
   criteria.

Inclusion criteria for healthy controls:

   1. Between 18 - 70 years of age.

   2. Have a HAM-D score of less than or equal to 5.

Exclusion Criteria for depressed patients:

   1. Electroconvulsive Therapy (ECT) in the 6 months prior to the study.

   2. Abuse of drugs or alcohol in the 6 months prior to study.

   3. Unstable or untreated hypertension or cardiovascular disease.

   4. Use of additional prescription medications, street drugs, or alcohol during the week
   before the study.

   5. Any Axis II diagnosis or traits which would make participation in the study difficult.

   6. Current pregnancy or lactation.

   7. Post-partum depression

   8. Diagnosis of obsessive-compulsive disorder

   9. History of significant cognitive decline

Exclusion criteria for healthy controls:

   1. Personal history of Axis I or Axis II disorders.

   2. Active unstable medical problems.

   3. Abuse of drugs or alcohol in the 6 months prior to study.

   4. Use of additional prescription medications, street drugs, or alcohol during the week
   before the study.

   5. Currently pregnant or lactating.

   6. History of significant cognitive decline

Ages Eligible for Study

18 Years - 70 Years

Genders Eligible for Study

All

Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Maureen H Chang, B.S.
650-725-4620
Recruiting