Trial Search Results

The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients.

The purpose of this study is to evaluate the potential secondary beneficial effect of prostaglandin analogues (PA) treatment in thyroid eye disease (TED) patients. This study aims to determine if PA would change the course of the orbitopathy in TED patients by altering the progression of the common features of TED, including fatty hypertrophy, proptosis, eyelid retraction and optic nerve compression. The eyes with thyroid eye disease and elevated intraocular pressure will be randomised to the PA treatment and the other eye will serve as a control eye and will be treated with Timolol.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):

Intervention(s):

  • Drug: Prostaglandin Analog
  • Drug: Timolol

Phase:

Phase 4

Eligibility


Inclusion Criteria:

   - mild or moderate to severe thyroid eye disease in one or both eyes

   - age > 18 years

   - informed consent

   - intraocular pressure > 21 mmHg or glaucoma suspect or glaucoma diagnosed in one or
   both eyes

   - not on current prostaglandin analog intraocular pressure lowering therapy

Exclusion Criteria:

   - sight threatening thyroid eye disease

   - children < 18 years old

   - patients that are not compliant with treatment or follow-up

   - patients already on prostaglandin analog treatment

   - patients that undergo cosmetic periocular procedures during the study will be excluded
   from further follow up

   - patients that cannot tolerate prostaglandin analog treatment.

   - patients with bilateral thyroid eye disease and elevated intraocular pressures that
   cannot tolerate treatment with timolol or an alternative intraocular pressure lowering
   medication such as trusopt, combigan, cosopt.

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Barbara Bartlett
650-724-9259
Not Recruiting