Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations

Inclusion Criteria:

   - Provide written informed consent

   - Histologically confirmed cancers for which no curative therapy exists

   - Documented HER2 or EGFR exon 18 mutation

   - Participants must agree and commit to use appropriate methods of contraception as
   outlined in the protocol

   - At least one measurable lesion, defined by RECIST v1.1

Exclusion Criteria:

   - Participants harboring ineligible somatic HER2 mutations

   - Prior treatment with any HER2-directed tyrosine kinase inhibitor (e.g., lapatinib,
   afatinib, dacomitinib, neratinib) is excluded with the following exception: patients
   with EGFR exon 18 mutated NSCLC who may have received afatinib, osimertinib, or other
   pan HER or EGFR TKIs remain eligible

   - Participants who are receiving any other anticancer agents

   - Symptomatic or unstable brain metastases

   - Women who are pregnant or breast-feeding

There are additional inclusion and exclusion criteria. The study center will determine if
criteria for participation are met.