Trial Search Results

High-Field MRI Iron-Based Contrast-Enhanced Characterization of Multiple Sclerosis and Demyelinating Diseases

Feraheme (ferumoxytol) is FDA-approved for iron supplementation and is composed of iron oxide nanoparticles classified among the ultra-small superparamagnetic iron oxides (USPIO). In this project we hypothesize that Feraheme could become a sensitive and specific marker of active inflammation in multiple sclerosis. We will explore this hypothesis taking advantage of ultra high field strength (7T) MRI to further increase the effectiveness of the contrast agent Feraheme at revealing inflammatory activity.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):

Intervention(s):

  • Drug: Feraheme
  • Drug: Gadolinium-based contrast

Eligibility


Inclusion Criteria:

   - Patients will be included if they are at least 18 years old and meet the revised
   diagnostic criteria for multiple sclerosis, relapsing remitting type.

   - Patients will be included based on MR evidence of disease activity after Gadolinium
   (enhanced lesion) on a previous screening MR in the previous 3 weeks days before
   Feraheme administration.

Exclusion Criteria:

   - Children (age < 18)

   - Those who lack decision-making capability

   - Contraindication to MRI such as pacemaker, other MR-incompatible metal implants or
   claustrophobia

   - Known allergy to dextran or drugs containing iron salts or any previous history of
   severe allergic reactions

   - Evidence of iron overload such as hemochromatosis or other hematologic disorders that
   imply iron level superior to the normal level.

   - Pregnancy or breast feeding.

   - History of renal disease or estimated glomerular filtration rate (eGFR) using the
   Modification of Diet in Renal Disease (MDRD) <40ml/min/1.73m?

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Not Recruiting