Trial Search Results

Exercise to Prevent Muscle Mass and Functional Loss in Elderly Dialysis Patients

The majority of individuals with advanced ESRD have reduced exercise capacity in part due to decreased muscle mass. This leads to a reduced ability to perform daily activities, a greater incidence of falls, and a reduced quality of life. The mechanisms responsible for the loss of muscle mass in ESRD are not understood very well. This study is designed to determine the effectiveness of an exercise program on improving muscle mass, exercise capacity and quality of life in persons with ESRD. In addition, the study will attempt to better understand why muscle loss occurs in people with ESRD, the influence exercise has on these mechanisms, and whether the response to exercise can be enhanced with nutrient supplementation.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

VA Office of Research and Development

Stanford Investigator(s):

Intervention(s):

  • Other: Exercise training
  • Other: Usual Care

Phase:

N/A

Eligibility


Inclusion Criteria:

   - Males and females aged 55-80 years undergoing maintenance hemodialysis (MHD) for at
   least three months and without other active/uncontrolled disease will be studied.

   - Exercise and usual care groups will be matched by age, body mass index (BMI), MHD
   duration, and protein intake using a stratified randomization approach.

   - Subjects will be required to be in the peak VO2 range of 10 to 20 ml/kg/min,
   equivalent to moderate functional impairment in patients with heart failure.

   - Subjects will be required to have dialysis treatment for >3 months with an average
   Kt/V 1.2, and be able to perform exercise safely.

Exclusion Criteria:

   - Current activity > 2 hrs/wk of moderate intensity exercise, temporary vascular access,
   uncontrolled diabetes mellitus, active vasculitis, active autoimmune disease,
   malignancy, severe obesity (BMI > 35), alcoholism or other recreational drug use,
   unstable cardiac disease (abnormal exercise test, angina, uncontrolled arrhythmias or
   myocardial infarction within three months), peripheral vascular disease (claudication
   with exercise), lung, liver or intestinal disease, those who are medically unstable
   and subjects who have received anabolic, catabolic or cytotoxic medications in the
   past 3 months.

   - The investigators will also exclude subjects with excessive previous exposure to
   radiation.

Ages Eligible for Study

55 Years - 80 Years

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Jonathan N Myers, PhD
650 4935000
Recruiting