Trial Search Results
Safety and Efficacy of Entospletinib With Vincristine and Dexamethasone in Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)
This study will evaluate the safety, efficacy, tolerability, and pharmacokinetics of entospletinib (GS-9973) in combination with vincristine (VCR), and dexamethasone in adults with previously treated relapsed or refractory B-cell lineage acute lymphoblastic leukemia (ALL).
This study consists of two parts: Dose Escalation and Dose Expansion. After 2 induction cycles during either parts of the study, participants may be put on maintenance for up to 36 cycles if they have obtained clinical benefit from the treatment.
Stanford is currently accepting patients for this trial.
- Drug: Entospletinib
- Drug: VCR
- Drug: Dexamethasone
- Drug: CNS Prophylaxis
Phase 1/Phase 2
Key Inclusion Criteria:
- Adults with ALL in need of treatment
Key Exclusion Criteria:
- Diagnosis of Burkitt's Leukemia, or lymphoid blast crisis of chronic myelogenous
- History of myelodysplastic syndrome or solid organ transplantation
- Prior allogeneic bone marrow progenitor cell transplant within 100 days or on active
immunosuppression for graft versus host disease (GVHD) treatment or prophylaxis within
28 days prior to enrollment
NOTE: Other protocol defined Inclusion/ Exclusion criteria may apply.
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study