Trial Search Results

Pharmacokinetic (PK) and Pharmacodynamic (PD) Modeling of Ampicillin and Gentamicin in Peripartum Patients

This study proposes to compare the metabolism of Ampicillin and Gentamicin by pregnant women to that of non-pregnant women; the placental transfer over time; and the subsequent metabolism of the transferred drug(s) in the neonate.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: David Drover, MD

Stanford Investigator(s):

Intervention(s):

  • Drug: Ampicillin
  • Drug: Ampicillin and Gentamicin
  • Drug: Gentamicin

Eligibility


Inclusion Criteria:

   - Generally healthy, pregnant woman (28-42 weeks)

   - Generally healthy, non-pregnant female

   - Scheduled to receive Ampicillin and/or Gentamicin IV

   - Ages 18-55 years old

   - Relatively normal Comprehensive Metabolic Panel (if available), as evidenced by recent
   blood work

   - Able and willing to sign consent

Exclusion Criteria:

   - Women with known renal or hepatic impairment; preeclampsia; Diabetes, including
   Gestational; any medical condition that, in the opinion of the Investigator or
   research team member, could potentially interfere with the study objectives

   - Women who are participating in another study

   - Pregnant with multiples

   - BMI > 40

Ages Eligible for Study

18 Years - 55 Years

Genders Eligible for Study

Female

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Brendan Carvalho, MBBCh
650-861-8607
Recruiting