Trial Search Results

Pilot Trial of Zoledronic Acid to Prevent Bone Loss in Hematopoietic Cell Transplant Recipients

Patients who undergo bone marrow transplant for different types of cancer are exposed to many treatments such as steroids and whole body radiation. These treatments make the transplant possible but also make their bones weaker and more prone to fractures which can be a source of significant disability and decreased quality of life for cancer survivors. Our trial will investigate whether giving one dose of Zoledronic acid (a commonly used drug given to preserve bone mass in osteoporosis) before bone marrow transplant can protect from the bone loss caused by the transplant procedures. The investigators are also interested in studying the complex interactions of bone, muscle and fat which are greatly affected after bone marrow transplant.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: National Institutes of Health (NIH)

Stanford Investigator(s):

Intervention(s):

  • Drug: Zoledronic acid

Phase:

N/A

Eligibility


Inclusion Criteria:

   - First allogeneic HSCT

   - Age > 18 years

   - Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

   - Current or prior use of bone active medication (bisphosphonates, teriparatide,
   selective estrogen receptor modulators, or Denosumab)

   - Hypo- (Ca < 8.5 mg/dL) or hyper-calcemia (Ca > 10.5 mg/dL)

   - Hyperthyroidism (TSH < 0.4 mIU/L and free T4 > 1.6 ng/dL)

   - Hyperparathyroidism (PTH > 80 pg/mL)

   - Estimated GFR < 35 ml/min/1.73 m2

   - Other chronic disease unrelated to HSCT that may impact bone metabolism

   - Osteoporosis: patients with a history of fragility fracture, or a Hip or Spine T score
   of <-2.5 (these patients will be treated with Zoledronic Acid and followed, but
   excluded from randomization)

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Rodrigo Valderrabano
Recruiting