Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus

Inclusion Criteria:

   - Men or women at least 40 years old. Women must be post-menopausal or using a highly
   effective method for avoidance of pregnancy.

   - Diagnosis of type 2 diabetes.

   - Established cardiovascular disease with at least one of the following: coronary artery
   disease, cerebrovascular disease, or peripheral arterial disease.

   - HbA1c >7.0% (53 mmol/mol) (based on the most recent documented laboratory measurement
   within 6 months).

   - Able and willing to provide informed consent.

Exclusion Criteria:

   - Severely reduced kidney function: eGFR <30 ml/min/1.73 m^2 (based on the last measured
   and documented laboratory measurement within 6 months) or renal replacement therapy.

   - Use of a GLP-1 receptor agonist at Screening.

   - Severe gastroparesis

   - History of pancreatitis or considered clinically at significant risk of developing
   pancreatitis during the course of the study.

   - Personal or family history of medullary carcinoma of the thyroid or subject with
   multiple endocrine neoplasia type 2 (MEN-2). Personal history of pancreatic
   neuroendocrine tumours.

   - Medical history which might limit the subject's ability to take trial treatments for
   the duration of the study or to otherwise complete the study.

   - Breastfeeding, pregnancy, or planning a pregnancy during the course of the study.
   Note: a pregnancy test will be performed on all women of child bearing potential prior
   to study entry.

   - Known allergy to any GLP-1 receptor agonist or excipients of albiglutide.

   - Use of another investigational product within 30 days or according to local
   regulations, or currently enrolled in a study of an investigational device.

   - Any other reason the investigator deems the subject to be unsuitable for the study.