Trial Search Results

Altitude Sickness Prevention and Efficacy of Comparative Treatments

This study is designed to be the first to examine the novel drug budesonide for prevention of acute mountain sickness in comparison to acetazolamide and in the context of rapid ascent to high altitude. The investigators will accomplish these objectives with a prospective, double blinded view of a large population of hikers who are ascending at their own rate in a true hiking environment.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):

Intervention(s):

  • Drug: Budesonide
  • Drug: Acetazolamide
  • Drug: Placebo

Phase:

Phase 3

Eligibility


Inclusion Criteria:

   1. Male and Female

   2. Sea level-dwelling hikers

   3. Between ages 18-65

Exclusion Criteria:

   1. History of allergy to acetazolamide or budesonide (or other corticosteroids)

   2. Taken NSAIDs, acetazolamide, or corticosteroids in the one week prior to study
   enrollment.

   3. Hazardous medical conditions which precludes the ability to moderately hike to high
   altitude including: sickle cell anemia, asthma, or COPD, severe anemia, or severe
   coronary arterial disease.

   4. Pregnancy or suspected pregnancy.

   5. Participants who are younger than 18 years of age and more than 65

   6. Sleep above 4'000 elevation in the preceding 1 week.

   7. History of asthma or COPD

   8. Current symptoms of an acute upper respiratory illness.

   9. Unable to complete a moderately strenuous hike at high altitude.

Ages Eligible for Study

18 Years - 65 Years

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Grant S Lipman, MD
415-290-9286
Not Recruiting