Trial Search Results

Refeeding Syndrome in Anorexia Nervosa

The purpose of this multi-center randomized controlled trial is to compare lower calorie refeeding to higher calorie refeeding for hospitalized adolescents and young adults with AN. The investigators will compare efficacy (achievement and maintenance of clinical remission at 12 months), safety during hospitalization, and cost effectiveness (including costs of initial and re hospitalization, 12 month follow up and safety/adverse events).

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: National Institutes of Health (NIH)

Stanford Investigator(s):

Intervention(s):

  • Behavioral: High calorie refeeding
  • Behavioral: Low calorie refeeding

Phase:

N/A

Eligibility


Inclusion Criteria:

   - Adolescents hospitalized for medical instability secondary to malnutrition will be
   eligible as follows.

Inclusion criteria:

   1. diagnosis of AN, atypical AN

   2. age 12-24 years

   3. no hospital admissions for the previous six months

   4. meet hospitalization criteria (daytime HR < 50 bpm or night time HR < 45 bpm, BP
   <90/45 mmHg, temperature < 36? C or orthostasis defined by increase in HR > 20 bpm or
   decrease in systolic BP > 20 mmHg or decrease in diastolic BP > 10 mmHg from lying to
   standing)

Exclusion Criteria:

   1. diagnosis of bulimia nervosa [DSM-5]

   2. current pregnancy

   3. admission for food refusal without malnutrition

   4. chronic disease (e.g. immune/endocrine disorders,pulmonary, cardiac, or renal disease)

   5. current suicidality or psychosis.

Ages Eligible for Study

12 Years - 24 Years

Genders Eligible for Study

All

Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305