Trial Search Results

Longitudinal Gene Expression Profiling in Adults After Traumatic Injury

The purpose of this study is to examine the immune response to traumatic injury and subsequent infections in critically ill adults. Traumatic injuries lead to severe dysregulation of the immune system, and predispose to severe infections. Diagnosing these infections in a timely manner is paramount in reducing morbidity and mortality, but diagnosis is made difficult by the inflammatory response to trauma. The main purpose of the study is to prospectively test the diagnostic power of the expression of an 11-gene set which the investigators recently published (Sweeney et al., Sci Transl Med, 2015). Since the timing of an acquired infection cannot be determined a priori, this study is designed to be a longitudinal examination of a cohort of traumatically injured adults. The investigators will draw blood at regular intervals, as well as at day of diagnosis of infection for any patient that are diagnosed with an infection. The investigators will then assay the blood for gene expression levels post hoc, and correlate the molecular profiles with clinical information to establish a prospective estimate of diagnostic power.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Stanford University

Collaborator: University Medical Center Goettingen

Stanford Investigator(s):

Intervention(s):

  • Other: 11-gene set

Eligibility


Inclusion Criteria:

   - Consecutive adults (>=18 years old) admitted to the ICU after blunt traumatic injury.

Exclusion Criteria:

   - Patients with isolated traumatic head or spinal cord injuries will not be included.

   - Furthermore, patients with prior or under continuous antibiotic therapy will be
   excluded (e.g. in case of intestinal perforation).

   - We will not exclude patients who are given <=24 hours of perioperative antibiotics.

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Timothy E Sweeney, MD, PhD
720-201-6689
Not Recruiting