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Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery
Recruiting
I'm InterestedTrial ID: NCT02675244
Purpose
The purpose of the research is to determine whether repairing a tricuspid valve (TV) in
patients with mild to moderate tricuspid regurgitation (TR), at the time of planned mitral
valve surgery (MVS), would improve the heart health of those who receive it compared to those
who do not.
At this point, the medical community is split in their opinion on whether surgeons should
routinely repair mild to moderate TR in patients who are undergoing planned mitral valve
surgery, and this study will answer this question.
Official Title
Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery
Stanford Investigator(s)
Joseph Woo, MD, FACS, FACC, FAHA
Norman E. Shumway Professor, Professor of Cardiothoracic Surgery and, by courtesy, of Bioengineering
Eligibility
Inclusion Criteria:
- Undergoing MVS for degenerative MR* with (a) Moderate TR as determined by
transthoracic 2D echocardiography, or (b) Tricuspid annular dimension ≥ 40 mm (index:
≥21mm/M2 BSA) and none/trace or mild TR, determined by echocardiography.
- Age ≥ 18 years
- Able to sign Informed Consent and Release of Medical Information forms
- "Degenerative mitral valve disease refers to a spectrum of conditions in which
morphologic changes in the connective tissues of the mitral valve cause
structural lesions . . ., such as chordal elongation, chordal rupture, leaflet
tissue expansion, and annular dilation typically resulting in mitral
regurgitation due to leaflet prolapse." This definition excludes rheumatic heart
disease. (Anyanwu AC, Adams DH. (2007) Etiological classification of degenerative
mitral valve disease: Barlow's disease and fibroelasticity deficiency. Semin
Thorac Cardiovasc Surg; 19(2): 90-6).
Exclusion Criteria:
- Functional MR
- Evidence of sub-optimal fluid management (e.g., lack of diuretics, weight in excess of
dry weight) in the opinion of the cardiology investigator
- Structural / organic TV disease
- Severe TV regurgitation as determined by preoperative transthoracic echocardiography
(TTE)
- Implanted pacemaker or defibrillator, where the leads cross the TV from the right
atrium into the right ventricle
- Concomitant cardiac surgery other than atrial fibrillation correction surgery (PVI,
Maze, LAA closure), closure of PFO or ASD, or CABG
- Cardiogenic shock at the time of randomization
- STEMI requiring intervention within 7 days prior to randomization
- Evidence of cirrhosis or hepatic synthetic failure
- Severe, irreversible pulmonary hypertension in the judgment of the investigator
- Pregnancy at the time of randomization
- Therapy with an investigational intervention at the time of screening, or plan to
enroll patient in additional investigational intervention study during participation
in this trial
- Any concurrent disease with life expectancy < 2 years
- Unable or unwilling to provide informed consent
- Unable or unwilling to comply with study follow up in the opinion of the investigator
Intervention(s):
procedure: TV Annuloplasty
procedure: MVS
Recruiting
I'm InterestedContact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Kokil Bakshi
650-498-1232