Management of Palmar Hyperhidrosis With Hydrogel-based Iontophoresis

Inclusion Criteria:

   - 13 years of age or older

   - >6 months self-reported history of primary palmar hyperhidrosis

   - Initial gravimetry test: >20mg/min on each palm

   - No topical treatments for hyperhidrosis (antiperspirants) on the palms for 2 weeks
   prior to the start of the study

   - No systemic treatments for hyperhidrosis (anticholinergics) for 4 weeks prior to the
   start of the study

   - No tap water iontophoresis treatment for 6 weeks

   - No Botox injections on the palms for 6 months (if single treatment session) or 10
   months (if >1 previous sessions) prior to the start of the study

   - No history of cardiothoracic sympathectomy for hyperhidrosis

   - Able to attend 3 office visits (Stanford Medical Outpatient Center located at 450
   Broadway St, Redwood City, CA 94063; Lucile Packard Children's Hospital at 730 Welch
   Road, 1st Floor, Palo Alto, CA 94304) and one virtual visit in an 8 week time frame

   - Capable of performing sweat level testing and hydrogel-based iontophoresis treatment
   at home, after training

   - Hydrogel electrode pad fits on the hand (typically tip of middle finger to lower end
   of palm length of 6.5in (16.5cm) or greater)

Exclusion Criteria:

   - Patients with implanted electronic medical devices e.g. pacemaker, implantable
   cardioverter/defibrillator)

   - Patients with metal implants in the extremity that will be treated

   - Patients with larger skin defects (on the palm or arm of the extremity that will be
   treated) that cannot be covered by petroleum jelly

   - Pregnant or nursing women, or looking to become pregnant

   - Patients on medications that interfere with neuroglandular transmission

   - Patients with active infection locally or systemically

   - Patients with history of contact dermatitis to acrylates

   - Patients with history of contact or systemic allergy to iodine

   - Patients with a history of ischemic heart disease, cardiac arrhythmias, epilepsy or
   thyroid disease