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Use of Repetitive Transcranial Magnetic Stimulation to Augment Hypnotic Analgesia
Not Recruiting
Trial ID: NCT02969707
Purpose
The investigators plan to use functional neuroimaging (fMRI) to understand the brain systems
affected when hypnosis and hypnotic analgesia are augmented with repetitive transcranial
magnetic stimulation (rTMS), a form of non-invasive brain stimulation to 100 people with
fibromyalgia, a chronic pain condition. The investigators will measure the effect of
rTMS-augmentation on the brain networks underlying hypnotizability, as well as the effect of
rTMS-augmentation on hypnotic analgesia networks. The investigators hope to demonstrate that
a combination of these psychological and neuromodulatory treatments will be more effective
than hypnosis alone, thereby enhancing the depth of hypnosis, range of hypnosis and the
efficacy of hypnotic analgesia and hopefully creating a new treatment modality for
individuals suffering from pain syndromes such as fibromyalgia pain.
Official Title
Use of Repetitive Transcranial Magnetic Stimulation to Augment Hypnotic Analgesia
Stanford Investigator(s)
Nolan Williams
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories & Clinical Translational Neurosciences Incubator) and, by courtesy, of Radiology (Neuroimaging and Neurointervention)
Eligibility
Inclusion Criteria:
- Fulfill 2010 Fibromyalgia Diagnostic Criteria
- Age 18 - 70
- Right-handed
- Agree to and able to have two fMRI scans as well as rTMS sessions
- Willingness to suspend use of analgesic drugs or cough suppressants for 24 hours prior
to the scans
- Willingness to suspend us of antidepressant drugs for 2 weeks prior to the scans (6
weeks for fluoxetine)
- Proficiency in English sufficient to complete questionnaires/follow instructions
during fMRI assessments
- US Citizen or resident able to receive payment legally
- Low-Moderate Hypnotizability in the Hypnotic Induction Profile (score of 0-8)
- Normal color vision
- Women of childbearing potential must agree to use adequate contraception prior to
study entry and continue this for the duration of the study
Exclusion Criteria:
- A medical condition that would contraindicate the use of rTMS
- Any condition that would contraindicate MRI (like ferromagnetic metal in the body)
- Pregnancy or breast feeding
- Any significant neurologic disease, including dementia, multi-infarct dementia,
Parkinson's or Huntington's disease, brain tumor, progressive supranuclear palsy,
seizure disorder, subdural hematoma, multiple sclerosis, history of significant head
trauma
- Current antidepressant use (must be washed out for two weeks prior to starting
protocol)
- Inability to stop taking medication contraindicated with treatment
- High Hypnotizability in the Hypnotic Induction Profile (score >8)
- Any significant psychiatric disorder as identified on the Mini Mental State Exam
(Dysthymia not an exclusion criteria)
- Color blindness
- Any significant psychiatric disorder as identified on the Mini International
Neuropsychiatric Interview
- Previous exposure to rTMS
Intervention(s):
device: MagPro TMS system (MagVenture, Denmark)
behavioral: Hypnosis
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Merve Gulser, BS
650-736-2233