Trial Search Results

The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis

The purpose of this study is to compare the clinical and functional outcomes of patients with mild to moderate arthroscopically confirmed osteoarthritis between the following two groups:

1. Partial fat pad harvest with Adipose-Derived Stem Cell (ADSC) transplantation with standard arthroscopic treatment consisting of: partial meniscectomy, cartilage stabilization, loose body removal and selective synovectomy.

2. Standard arthroscopic treatment (above) with out cell transplant.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Stanford University

Stanford Investigator(s):

Intervention(s):

  • Procedure: Arthroscopic debridement with stem cell transplantation
  • Procedure: Arthroscopic debridement only

Phase:

N/A

Eligibility


Inclusion Criteria:

   - Age between 35 and 70 years-old

   - Patient is scheduled to undergo one or a combination of the following procedures:

      - Meniscal debridement or partial menisectomy

      - Meniscal repair that does not necessitate a different postoperative protocol from
      meniscal debridement or partial menisectomy

      - Removal of loose bodies

      - Chondroplasty

      - Synovectomy

      - Soft tissue releases for flexion or extension contracture.

   - Diagnosis of pre-existing mild to moderate osteoarthritis of the medial or lateral
   femoral condyle (Kellgren-Lawrence Grade 2 or 3)

   - < 6 months of knee pain or < 6 months of a significant exacerbation of existing knee
   pain

   - Physical examination findings consistent with the proposed surgical procedure.

   - Failure of conservative therapy consisting of a minimum of 6 weeks of physical therapy
   and trial of anti-inflammatory medications, with or without concomitant bracing and/or
   injections

Exclusion Criteria:

   - Age < 35 or > 70 years old

   - Radiographs demonstrating either no, little or severe osteoarthritis
   (Kellgren-Lawrence Grade 0, 1 or 4)

   - Previous injury or surgery to the infrapatellar fat pad (assessed by MRI)

   - Patient scheduled to undergo any concomitant surgical procedures with the exception
   of:

      - Meniscal debridement or partial menisectomy

      - Meniscal repair that does not necessitate a different postoperative protocol from
      meniscal debridement or partial menisectomy

      - Removal of loose bodies

      - Chondroplasty

      - Synovectomy

      - Soft tissue releases for flexion or extension contracture

   - Prior surgery on ipsilateral knee involving cartilage regeneration (microfracture,
   Autologous Chondrocyte Implantation, etc) or meniscal transplant/implant

   - Previous arthroscopy within 1 year

   - Subchondral edema

Ages Eligible for Study

35 Years - 70 Years

Genders Eligible for Study

All

Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Jason L Dragoo, MD
Recruiting