Trial Search Results

DCM Precision Medicine Study

The aims of the DCM Precision Medicine Study are to test the hypothesis that DCM has substantial genetic basis and to evaluate the effectiveness of a family communication intervention in improving the uptake and impact of family member clinical screening.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Ray Hershberger

Collaborator: National Human Genome Research Institute (NHGRI)

Stanford Investigator(s):

Intervention(s):

  • Behavioral: Family Heart Talk Booklet

Phase:

N/A

Eligibility


Inclusion Criteria:

   - Meeting criteria for dilated cardiomyopathy (DCM) :

      - Left ventricular ejection fraction <50%

      - Left ventricular enlargement (A left ventricular end-diastolic dimension >
      95%tile population standard based on gender and height).

   - Detectable causes of cardiomyopathy, except genetic, excluded beyond a reasonable
   doubt at the time of DCM diagnosis (that is, meeting clinical criteria for idiopathic
   DCM)

   - Any age (including children)

   - Non-Hispanic and Hispanic ethnicity

   - All races (PI pre-approval required for recruitment beyond pre-specified recruitment
   targets).

   - Ability to give informed consent

   - Ability to communicate in English (except Spanish language at sites approved to
   recruit individuals of Hispanic ethnicity)

   - Willingness to participate in a family-based study (patient willing to work with a
   clinical site and/or OSU to facilitate the recruitment and enrollment of family
   members to the study).

Exclusion Criteria:

   - Coronary artery disease (CAD) causing ischemic cardiomyopathy (> 50% narrowing, any
   major epicardial coronary artery)

   - Primary valvular disease

   - Adriamycin or other cardiotoxic drug exposure

   - Other forms of cardiomyopathy: Hypertrophic, Restrictive, or Arrhythmogenic Right
   Ventricular Dysplasia/Cardiomyopathy

   - Congenital heart disease

   - Other detectable causes of dilated cardiomyopathy, including sarcoid and
   hemochromatosis.

   - Other active multi-system disease that may cause DCM (e.g., active connective tissue
   disease).

   - Severe and untreated or untreatable hypertension (systolic blood pressures routinely
   greater than 180 mm Hg and/or diastolic blood pressures greater than 120 mm Hg, and if
   resistant to multidrug treatment).

   - However, conventional risk factors for DCM, including obesity, routinely treated
   hypertension, alcohol use, pregnancy or the peri-partum period, or left ventricular
   noncompaction, will NOT be considered exclusion criteria.

Ages Eligible for Study

N/A - N/A

Genders Eligible for Study

All

Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
DCM Coordinators
650 725-6911
Recruiting