Functional Magnetic Resonance Imaging in Assessing Affect Reactivity and Regulation in Patients With Stage 0-III Breast Cancer

Inclusion Criteria:

Women Diagnosed with breast cancer

   - Female

   - Age 18 or older

   - Agree to suspend treatments containing Benzodiazepines and steroids up to 2 weeks pre
   and during cortisol sampling (based on PI's clinical judgement)

   - Agree to taking saliva samples and having fMRI scan

   - No contraindications to MRI imaging (like ferromagnetic metal in their body)

   - Proficiency in English sufficient to complete questionnaires and follow instructions
   during the fMRI assessments

   - US Citizen or resident able to receive payment legally

   - Documented stage 0-III breast cancer

   - Unilateral breast tumors

Controls

   - Female

   - Age 18 or older

   - Agree to suspend treatments containing Benzodiazepines and steroids up to 2 weeks pre
   and during cortisol sampling (based on PI's clinical judgement)

   - Agree to having saliva samples and fMRI scan

   - No contraindications to MRI imaging (like ferromagnetic metal in their body)

   - Proficiency in English sufficient to complete questionnaires and follow instructions
   during the fMRI assessments

   - US Citizen or resident able to receive payment legally

Exclusion Criteria:

Women Diagnosed with breast cancer

   - Other active cancers within the past 10 years other than squamous cell carcinoma of
   the skin

   - Pregnant

   - Any significant neurologic disease, such as dementia, multi-infarct dementia,
   Parkinson's or Huntington's disease, brain tumor, progressive supranuclear palsy,
   seizure disorder, subdural hematoma, multiple sclerosis, stroke, or traumatic brain
   injury

   - Hearing impaired

   - Current untreated psychosis, or bipolar disorder, or substance/alcohol
   abuse/dependence

   - Current use of psychotropic (based on PI's clinical judgement) medication 5 or more
   days a week

Controls

   - Cancer diagnosis, current or past

   - Pregnant

   - Any significant neurologic disease, such as dementia, multi-infarct dementia,
   Parkinson's or Huntington's disease, brain tumor, progressive supranuclear palsy,
   seizure disorder, subdural hematoma, multiple sclerosis, stroke, or traumatic brain
   injury

   - Hearing impaired

   - Current untreated psychosis, or bipolar disorder, or substance/alcohol
   abuse/dependence

   - Current use of psychotropic (based on PI's clinical judgement) medication 5 or more
   days a week

   - Breast cancer diagnosis in 1 first degree relative or 2 or more second degree
   relatives

   - Ovarian cancer diagnosis in 1 first or second degree relative