©2024 Stanford Medicine
Diagnostic Performance of Coronary CT Angiography With CT FFR in Kidney Transplantation Candidates
Not Recruiting
Trial ID: NCT03248674
Purpose
Patients with chronic kidney disease (CKD) before kidney transplantation require that
obstructive coronary artery disease (CAD) is excluded, as cardiovascular complications are
the leading cause of mortality in kidney transplant patients. However, in this patient
population, the optimal method for the detection of obstructive CAD has not been identified.
Noninvasive stress tests such as Dobutamine stress echocardiography or nuclear perfusion
study have low diagnostic accuracy. CT fractional flow reserve measurement (CT FFR) is a
novel non-invasive (FDA approved) imaging test to identify obstructive CAD. The goal of this
project is to evaluate the diagnostic accuracy of CT FFR in the detection of obstructive
coronary artery disease in patients with chronic kidney disease before kidney
transplantation.
Official Title
Diagnostic Performance of Coronary Computed Tomography Angiography With Computed Tomography Fractional Flow Reserve in Kidney Transplantation Candidates
Stanford Investigator(s)
Dominik Fleischmann
Professor of Radiology (Cardiovascular Imaging)
Eligibility
Inclusion Criteria:
- Candidates for kidney transplantation on dialysis without any residual kidney function
AND referred to invasive coronary angiography for cardiac evaluation
- Referral to invasive coronary angiography is based on algorithm used at the Transplant
Readiness Assessment Clinic (TRAC) at Stanford:
- A. Diabetic Candidates older than 45 years.
- B. Diabetic Candidates under 45 years old and any one of the following criteria is
present:
- a) 25 year History of Diabetes
- b) 5 year Smoking History
- c) Abnormal EKG (ST-T wave changes)
Exclusion Criteria:
- Hemodynamically and clinically unstable condition (angina at rest, malignant
arrhythmias)
- Known ischemic heart disease (prior, documented myocardial infarction, prior stenting
or coronary artery bypass graft surgery)
- BMI>30 kg/m2, or weight >120 kg.
- Atrial fibrillation or other arrhythmia, >6 ectopic beats per minute
- Known or suspected allergy to iodinated contrast medium
- Pregnancy cannot be excluded
Intervention(s):
diagnostic test: CT FFR
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Dominik Fleischmann, MD
650-723-7647