Trial Search Results
Improving Cognition Via Exercise in Schizophrenia
People with schizophrenia display a broad range of cognitive impairments that have been identified as major determinants of poor functioning and disability. The goal of the proposed study is to examine the impact of exercise training on cognition, daily functioning, and biomarkers of cognitive change in people with schizophrenia.
Stanford is currently accepting patients for this trial.
Icahn School of Medicine at Mount Sinai
Collaborator: National Institute of Mental Health (NIMH)
- Behavioral: Aerobic Exercise
- Behavioral: Stretching and Toning Exercise
- A DSM-V diagnosis of schizophrenia, schizoaffective, or schizophreniform disorder.
- Age 18-55 years.
- Taking antipsychotic medication for at least 8 weeks and on current doses for 4 weeks,
and/or injectable depot antipsychotics with no change in the last 3 months.
- Capacity to understand all the potential risks and benefits of the study.
- Medically cleared by a physician to take part in VO2max tests and aerobic exercise
training or stretching-and-toning exercise training.
- A DSM-V diagnosis of alcohol/substance abuse (except nicotine) within the last month
or a diagnosis of alcohol/substance dependence (except nicotine) within the last 6
- Initiation of anti-depressants, mood stabilizers, or other medications known to impact
cognition in previous 4 weeks or any change in doses during this period.
- History of seizures/head trauma with loss of consciousness (>10 minutes) resulting in
- Significant clinical abnormalities in physical examination, lab assessments, or ECG.
- Neurological/medical conditions that could interfere with study participation (e.g.,
unstable cardiac disease, stuttering).
- Body Mass Index (BMI) ≥ 40.
- Untreated hyper- or hypothyroidism.
- Being pregnant or nursing.
- Serious homicidal/suicidal risk (past 6 months).
- "Moderate" or more severe conceptual disorganization (PANSS≥4).
- Poor English reading ability (WTAR<7).
- Participation in a study with cognitive assessment in the past 3 months.
Ages Eligible for Study
18 Years - 55 Years
Genders Eligible for Study