A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors

Inclusion Criteria:

   - Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

   - Life expectancy greater than or equal to (>=12 weeks)

   - Adequate hematologic and end-organ function

   - Measured or calculated creatinine clearance >=50 milliliters per minute (mL/min) on
   the basis of the Cockcroft-Gault glomerular filtration rate estimation

Cancer-Specific Inclusion Criteria:

   - Participants with histologic documentation of locally advanced, recurrent, or
   metastatic incurable malignancy that has progressed after at least one available
   standard therapy; or for whom standard therapy has proven to be ineffective or
   intolerable, or is considered inappropriate; or for whom a clinical trial of an
   investigational agent is a recognized standard of care

   - Participants with confirmed availability of representative tumor specimens in
   formalin-fixed, paraffin-embedded (FFPE) blocks (preferred), or sectioned tissue

   - Participants with measurable disease per RECIST v1.1

Additional Inclusion Criteria for Participants in Each Indication-Specific
Exploration/Expansion Cohort of Phase 1b:

   - NSCLC Cohorts (CIT-Naive): Participants with histologically confirmed incurable,
   advanced NSCLC not previously treated with anti-PD-L1/PD-1 and/or with anti-CTLA-4
   (investigational or approved), for whom a clinical trial of an investigational agent
   in combination with an anti-PD-L1/PD-1 antibody is considered an acceptable treatment
   option (if CIT [including anti-PD-L1/PD-1 agents] is approved as treatment for NSCLC
   by local regulatory authorities).

   - NSCLC Cohort (CIT-Treated): Participants with histologically confirmed incurable,
   advanced NSCLC previously treated with anti-PD-L1/PD-1 with or without anti-CTLA-4
   (investigational or approved)

   - Triple negative breast cancer (TNBC) Cohort (CIT-Naive): Participants with
   histologically confirmed incurable, advanced estrogen receptor (ER)-negative,
   progesterone receptor-negative, and human epidermal growth factor receptor 2
   (HER2)-negative adenocarcinoma of the breast (triple-negative) not previously treated
   with anti-PD-L1/PD-1 and/or anti-CTLA-4 (investigational or approved)

   - Colorectal cancer (CRC) Cohort (CIT-Naive): Participants with histologically confirmed
   incurable, advanced adenocarcinoma of the colon or rectum not previously treated with
   anti-PD-L1/PD-1 and/or anti-CTLA-4 (investigational or approved)

   - Head and neck squamous cell carcinoma (HNSCC) Cohort (CIT-Naive): Participants with
   histologically confirmed inoperable, locally advanced or metastatic, recurrent, or
   persistent HNSCC (oral cavity, oropharynx, hypopharnyx, or larynx) not amenable to
   curative therapy not previously treated with anti-PD-L1/PD-1 and/or anti-CTLA-4
   (investigational or approved)

   - Urothelial carcinoma (UC) Cohort (CIT-Naive): Participants with histologically
   confirmed incurable, advanced transitional cell carcinoma of the urothelium including
   renal pelvis, ureters, urinary bladder, and urethra, not previously treated with
   anti-PD-L1/PD-1 with or without anti-CTLA-4 (investigational or approved), for whom a
   clinical trial of an investigational agent in combination with an anti-PD-L1 antibody
   is considered an acceptable treatment option, if CIT (including anti-PD-L1/PD-1
   agents) is approved as treatment for UC by local regulatory authorities

   - UC Cohort (CIT-Treated): Participants with histologically confirmed incurable advanced
   transitional cell carcinoma of the urothelium (including renal pelvis, ureters,
   urinary bladder, and urethra) previously treated with anti-PD-L1/PD-1 with or without
   anti-CTLA-4 (investigational or approved)

   - Renal cell carcinoma (RCC) Cohort (CIT-Naive): Participants with histologically
   confirmed incurable, advanced RCC with component of clear cell histology and/or
   component of sarcomatoid histology not previously treated with anti-PD-L1/PD-1 and/or
   anti-CTLA-4 (investigational or approved)

   - Melanoma Cohort (CIT-Naive in metastatic setting): Participants with histologically
   confirmed incurable, advanced melanoma not previously treated with anti-PD-L1/PD-1
   and/or anti-CTLA-4 (investigational or approved) in the metastatic setting

   - Melanoma Cohort (CIT-Treated): Participants with histologically confirmed incurable,
   advanced melanoma previously treated with anti-PD-L1/ or PD-1 with or without CTLA-4
   (investigational or approved)

Additional Inclusion Criteria for Participants in the Serial-Biopsy Expansion Cohort of
Phase 1b:

   - Participants must have one of the locally advanced or metastatic solid tumor types
   specified in the protocol.

   - Participants must have accessible lesion(s) that permit a total of two to three
   biopsies (pretreatment and on-treatment) or one biopsy (on-treatment, if archival
   tissue can be submitted in place of a pre-treatment biopsy) without unacceptable risk
   of a significant procedural complication. RECIST lesions should not be biopsied.

Exclusion Criteria:

   - Known clinically significant liver disease, including active viral, alcoholic, or
   other hepatitis, cirrhosis, and inherited liver disease or current alcohol abuse

   - Major surgical procedure within 28 days prior to Cycle 1, Day 1, or anticipation of
   need for a major surgical procedure during the course of the study

   - Any other diseases, metabolic dysfunction, physical examination finding, and/or
   clinical laboratory finding giving reasonable suspicion of a disease or condition that
   contraindicates the use of an investigational drug or that may affect the
   interpretation of the results or may render the participant at high risk from
   treatment complications

   - Previous splenectomy

   - Known primary immunodeficiencies, either cellular (e.g., DiGeorge syndrome, T-negative
   severe combined immunodeficiency [SCID]) or combined T- and B-cell immunodeficiencies
   (e.g., T- and B-negative SCID, Wiskott Aldrich syndrome, ataxia telangiectasia, common
   variable immunodeficiency)

   - Any medical condition or abnormality in clinical laboratory tests that, in the
   investigator's judgment, precludes the participant's safe participation in and
   completion of the study Cancer-Specific Exclusion Criteria

   - Any anti-cancer therapy, whether investigational or approved, including chemotherapy,
   hormonal therapy, and/or radiotherapy, within 3 weeks prior to initiation of study
   treatment, with the exceptions as mentioned in the protocol

   - Eligibility based on prior treatment with CIT depends on the mechanistic class of the
   drug and the cohort for which the participant is being considered, as described below.
   In addition, all criteria pertaining to adverse events attributed to prior cancer
   therapies must be met

All Cohorts (Dose-Escalation in Phase 1a and Dose-Escalation, Backfill, and Expansion in
Phase 1b):

   - Prior neoantigen-specific or whole-tumor cancer vaccines are not allowed, with the
   exception as specified in protocol

   - Prior treatment with cytokines is allowed provided that at least 6 weeks or 5
   half-lives of the drug, whichever is shorter, have elapsed between the last dose and
   the proposed Cycle 1, Day 1

   - Prior treatment with immune checkpoint inhibitors, immunomodulatory monoclonal
   antibody (mAbs), and/or mAb-derived therapies is allowed provided that at least 6
   weeks (Phase 1a) or 3 weeks (Phase 1b) have elapsed between the last dose and the
   proposed Cycle 1, Day 1, with the exceptions as specified in protocol Phase Ib
   Dose-Exploration/Expansion Group Only Cohorts

   - In the non-melanoma CIT-Naive expansion cohort in Phase Ib, prior treatment with
   anti-PD-L1/PD-1 and/or anti-CTLA-4 (investigational or approved), is not allowed.

   - In the melanoma CIT-naive in metastatic setting expansion cohort in Phase Ib, prior
   treatment with anti-PD- L1/PD-1 and/or anti-CTLA-4 (investigational or approved) is
   not allowed. Prior anti-PD-L1/PD-1 and/or anti-CTLA-4 therapy in the adjuvant setting
   is allowed provided that there is at least a 6-month treatment-free interval between
   completion of adjuvant therapy and Cycle 1, Day 1.

   - Prior treatment with immunomodulators, including toll-like receptor (TLR) agonists,
   inhibitors of indoleamine 2,3-dioxygenase (IDO)/ tryptophan-2,3-dioxygenase (TDO), or
   agonists of OX40, is allowed provided that at least 5 half-lives of the drug or a
   minimum of 3 weeks have elapsed between the last dose of the prior treatment and the
   proposed Cycle 1, Day 1, with the exception as specified in protocol

   - Any history of an immune-mediated Grade 4 adverse event attributed to prior CIT (other
   than endocrinopathy managed with replacement therapy or asymptomatic elevation of
   serum amylase or lipase)

   - Any history of an immune-mediated Grade 3 adverse event attributed to prior CIT (other
   than hypothyroidism managed with replacement therapy) that resulted in permanent
   discontinuation of the prior immunotherapeutic agent and/or occurred less than or
   equal to (<=) 6 months prior to Cycle 1 Day 1

   - Adverse events from prior anti-cancer therapy that have not resolved to Grade <=1
   except for alopecia, vitiligo, or endocrinopathy managed with replacement therapy

   - All immune-mediated adverse events related to prior CIT (other than endocrinopathy
   managed with replacement therapy or stable vitiligo) must have resolved completely to
   baseline

   - Primary central nervous system (CNS) malignancy, untreated CNS metastases, or active
   CNS metastases (progressing or requiring corticosteroids for symptomatic control)

   - Leptomeningeal disease

   - Uncontrolled tumor-related pain

   - Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent
   drainage procedures

   - Malignancies other than disease under study within 5 years prior to Cycle 1, Day 1,
   with the exception of those with a negligible risk of metastasis or death

   - Uncontrolled hypercalcemia

   - Participant has spinal cord compression not definitively treated with surgery and/or
   radiation or previously diagnosed and treated spinal cord compression without evidence
   that disease has been clinically stable for >=2 weeks prior to screening

Treatment-Specific Exclusion Criteria:

   - History of autoimmune disease with caveats as specified in protocol

   - Treatment with monoamine oxidase inhibitors (MAOIs) within 3 weeks prior to Cycle 1,
   Day 1

   - Treatment with systemic immunosuppressive medications within 2 weeks prior to Cycle 1,
   Day 1

   - History of idiopathic pulmonary fibrosis, pneumonitis, organizing pneumonia, or
   evidence of active pneumonitis on screening chest computed tomography (CT) scan

   - Positive test for human immunodeficiency virus (HIV) infection

   - Active hepatitis B, hepatitis C

   - Known active or latent tuberculosis infection

   - Severe infections within 4 weeks prior to Cycle 1, Day 1

   - Recent infections not meeting the criteria for severe infections within 2 weeks prior
   to Cycle 1, Day 1

   - Prior allogeneic bone marrow transplantation or prior solid organ transplantation

   - Administration of a live, attenuated vaccine within 4 weeks before Cycle 1, Day 1 or
   anticipation that such a live attenuated vaccine will be required during the study

   - Known hypersensitivity to the active substance or to any of the excipients in the
   vaccine

   - Phase 1b and crossover only: History of severe allergic, anaphylactic, or other
   hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins;
   Known hypersensitivity to Chinese Hamster Ovary (CHO)-cell products; Allergy or
   hypersensitivity to components of the atezolizumab formulation